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Table 1 Main characteristics of the included studies

From: Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controls

Study Year Region Ethnicity Sample size Quality score HWE Y/N GG (n) GT (n) TT (n)
(Case/control) Case Control Case Control Case Control
Lacolley 1997 France Caucasian 309/ 123 7 0.250 140 35 122 67 47 21
Miyamoto 1998 Japan Asian 218/ 240 8 0.587 175 217 41 22 2 1
Benjafield 2000 Australia Caucasian 91/ 149 7 0.314 40 70 43 68 8 11
Shoji 2000 Japan Asian 183/ 193 7 0.462 139 164 41 27 3 2
KARVONEN 2002 Finland Caucasian 505/ 519 9 0.820 244 262 220 215 41 42
Di 2002 China Asian 95/ 95 7 0.511 70 83 25 12 0 0
Liu 2002 China Asian 103/ 74 7 0.205 54 55 44 19 5 0
Jia 2002 China Asian 116/ 136 8 0.316 83 114 29 20 4 2
Tan 2003 China Asian 112/ 112 8 0.012 73 78 25 26 14 8
Li 2004 China Asian 310/ 151 8 0.902 226 126 81 24 3 1
Xu 2004 China Asian 203/ 190 8 0.854 165 141 37 45 1 4
Djuric´ 2005 Serbia Caucasian 172/ 200 7 0.782 84 93 71 88 17 19
Moe 2006 Singapore Asian 103/ 104 7 0.787 79 82 20 21 4 1
Marcun-Varda 2006 Slovenia Caucasian 104/ 200 7 0.901 43 74 49 96 12 30
Dong 2006 China Asian 97/ 87 7 0.983 41 62 50 23 6 2
Ma 2006 China Asian 192/ 122 7 0.274 76 46 89 53 27 23
Wang 2006 China Asian 277/ 547 7 0.284 233 468 40 74 4 5
Zhang 2006 China Asian 375/ 414 7 < 0.001 212 273 106 93 57 48
Liang 2006 China Asian 124/ 100 8 0.625 108 85 11 14 5 1
Zhang 2006 China Asian 190/ 94 8 0.791 164 89 19 5 7 0
Zhao 2006 China Asian 501/ 489 7 0.692 404 387 93 97 4 5
Khawaja 2007 Pakistan Mixed 143/ 184 6 0.689 99 129 37 51 7 4
Wang 2007 China Asian 100/ 50 7 0.101 70 44 27 5 3 1
Colomba 2008 Italy Caucasian 127/ 67 7 0.030 45 19 70 41 12 7
Nejatizadeh 2008 India Asian 453/ 344 7 0.006 259 222 118 98 76 24
Periaswamy 2008 India Asian 438/ 444 8 0.656 291 323 126 110 21 11
Srivastava 2008 India Asian 226/ 200 8 0.556 139 154 82 44 5 2
Ghazali 2008 Malaysia Asian 200/ 198 8 0.920 144 151 54 44 2 3
Tang 2008 China Asian 184/ 196 6 0.983 91 95 80 83 13 18
Zhao 2008 China Asian 174/ 112 7 0.733 138 105 32 7 4 0
Tang 2008 China Asian 271/ 267 6 < 0.001 171 169 73 65 27 33
Wang 2009 China Asian 230/ 186 8 0.518 9 12 46 64 175 110
Zhang 2009 China Asian 349/ 214 8 0.267 260 179 79 32 10 3
Liu 2009 China Asian 129/ 117 7 0.311 76 85 46 31 7 1
Niu 2009 China Asian 1305/ 1154 8 0.008 1071 954 192 182 42 18
Kitsios 2010 Greece Caucasian 228/ 302 6 0.512 99 135 95 130 34 37
Wang 2010 China Asian 154/ 150 8 0.240 98 116 40 30 16 4
Zhou 2010 China Asian 176/ 131 6 0.351 137 98 38 32 1 1
Souza-Costa 2011 Brazil Mixed 73/ 285 8 0.086 45 172 25 105 3 8
Zhou 2011 China Asian 346/ 385 8 0.667 280 312 62 70 4 3
Chen 2011 China Asian 160/ 176 8 0.161 138 154 21 20 1 2
Zhao 2011 China Asian 100/ 97 8 0.648 96 82 3 14 1 1
Li 2011 China Asian 510/ 510 7 < 0.001 320 367 129 89 61 54
Ma 2012 China Asian 300/ 288 8 0.577 255 250 43 36 2 2
Zhang 2012 China Asian 363/ 370 6 0.580 265 278 85 84 13 8
Liang 2012 China Asian 350/ 150 7 0.965 290 127 57 22 3 1
Li 2012 China Asian 227/ 359 7 0.549 185 296 40 61 2 2
Goncharov 2013 Ukraine Caucasian 145/ 144 7 < 0.001 65 45 60 93 20 6
Yan 2013 China Asian 308/ 181 8 0.105 235 142 57 34 16 5
Yang 2013 China Asian 134/ 115 6 0.791 70 97 59 17 5 1
Ogretmen 2014 Turkey Caucasian 21/ 109 6 0.746 7 70 13 34 1 5
Shankarishan 2014 India Caucasian 350 /350 8 0.261 194 296 133 50 23 4
Cui 2014 China Asian 172 /90 8 0.786 133 85 36 5 3 0
Liu 2014 China Asian 215 /108 8 0.283 149 89 48 17 18 2
Hui 2015 China Asian 100 /100 6 0.677 81 92 16 8 3 0
Xiong 2015 China Asian 226 /186 8 0.752 130 133 83 48 13 5
ALrefai 2016 Egypt Caucasian 70 /30 7 0.773 49 27 16 3 5 0
Gamil 2017 Sudan Caucasian 147 /82 6 0.829 100 60 42 20 5 2
Zhang 2017 China Asian 456 /453 8 0.001 365 362 84 78 7 13
Nassereddine 2018 Morocco Caucasian 145 /184 6 0.509 5 116 54 62 86 6