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Table 4 Results of logistic regression models

From: IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study

Dependent variable Univariate Adjusted by age and sex Adjusted by age, sex and hypertension
OR (95% CI) p OR (95% CI) p OR (95% CI) p
IGFBP7
Atrial fibrillation 8.87 3.71–21.20 9.1 × 10−7 6.70 2.59–17.32 8.8 × 10−5 6.79 2.62–17.60 8.0 × 10−5
E/e’ 0.23 0.13–0.41 7.0 × 10−7 0.33 0.17–0.64 0.001 0.34 0.18–0.64 0.001
Enlarged LAA 21.64 5.77–81.21 5.0 × 10−−6 12.68 3.01–53.42 0.001 12.72 3.01–53.86 0.001
LVH 4.96 2.54–9.69 3.0 × 10−6 4.67 2.24–9.73 3.9 × 10−5 4.51 2.15–9.48 6.8 × 10−5
MFS 4.24 2.21–8.16 1.5 × 10−5 2.52 1.25–5.07 0.010 2.44 1.21–4.93 0.013
GDF–15
Atrial fibrillation 2.79 2.01–3.87 7.2 × 10−10 2.52 1.77–3.57 2.7 × 10−7 2.51 1.77–3.57 3.0 × 10−7
E/e’ 0.62 0.50–0.78 2.3 × 10−5 0.72 0.56–0.91 0.006 0.71 0.56–0.90 0.004
Enlarged LAA 2.45 1.45–4.13 0.001 1.67 0.90–3.07 0.103 1.70 0.92–3.14 0.091
LVH 1.70 1.33–2.19 3.4 × 10−5 1.67 1.27–2.19 2.8 × 10−4 1.72 1.30–2.27 1.4 × 10−4
MFS 2.18 1.70–2.81 1.2 × 10−9 1.85 1.41–2.42 8.0 × 10−6 1.89 1.44–2.48 4.0 × 10−6
P1NP
Atrial fibrillation 1.27 0.89–1.82 0.189 1.19 0.83–1.72 0.337 1.20 0.83–1.72 0.334
E/e’ 0.88 0.72–1.09 0.238 0.99 0.81–1.24 0.994 1.00 0.81–1.25 0.977
Enlarged LAA 1.44 0.80–2.57 0.222 1.32 0.74–2.36 0.354 1.31 0.73–2.34 0.369
LVH 1.12 0.87–1.44 0.376 0.96 0.74–1.25 0.777 0.96 0.74–1.25 0.761
MFS 0.92 0.72–1.17 0.494 0.90 0.71–1.15 0.416 0.91 0.71–1.16 0.445
  1. Logistic univariate and multivariate regression analyses with cardiac phenotype (dependent) and Ln-transformed IGFBP7, GDF-15 and P1NP
  2. E/e ‘ > 8 vs <  = 8; GDF-15, growth differentiation factor-15; IGFBP7, insulin grow factor binding protein; P1NP, amino-terminal propeptide of type I procollagen. LAA, left atrial area, enlarged if > 20; LVH: Left ventricular hypertrophy defined as LV mass/BSA > 95 g/m2 for women and > 115 g/m2 for men; MFS, midwall circumference fraction shortening, reduced if MFS < 15%