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Table 4 Results of logistic regression models

From: IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study

Dependent variable

Univariate

Adjusted by age and sex

Adjusted by age, sex and hypertension

OR

(95% CI)

p

OR

(95% CI)

p

OR

(95% CI)

p

IGFBP7

Atrial fibrillation

8.87

3.71–21.20

9.1 × 10−7

6.70

2.59–17.32

8.8 × 10−5

6.79

2.62–17.60

8.0 × 10−5

E/e’

0.23

0.13–0.41

7.0 × 10−7

0.33

0.17–0.64

0.001

0.34

0.18–0.64

0.001

Enlarged LAA

21.64

5.77–81.21

5.0 × 10−−6

12.68

3.01–53.42

0.001

12.72

3.01–53.86

0.001

LVH

4.96

2.54–9.69

3.0 × 10−6

4.67

2.24–9.73

3.9 × 10−5

4.51

2.15–9.48

6.8 × 10−5

MFS

4.24

2.21–8.16

1.5 × 10−5

2.52

1.25–5.07

0.010

2.44

1.21–4.93

0.013

GDF–15

Atrial fibrillation

2.79

2.01–3.87

7.2 × 10−10

2.52

1.77–3.57

2.7 × 10−7

2.51

1.77–3.57

3.0 × 10−7

E/e’

0.62

0.50–0.78

2.3 × 10−5

0.72

0.56–0.91

0.006

0.71

0.56–0.90

0.004

Enlarged LAA

2.45

1.45–4.13

0.001

1.67

0.90–3.07

0.103

1.70

0.92–3.14

0.091

LVH

1.70

1.33–2.19

3.4 × 10−5

1.67

1.27–2.19

2.8 × 10−4

1.72

1.30–2.27

1.4 × 10−4

MFS

2.18

1.70–2.81

1.2 × 10−9

1.85

1.41–2.42

8.0 × 10−6

1.89

1.44–2.48

4.0 × 10−6

P1NP

Atrial fibrillation

1.27

0.89–1.82

0.189

1.19

0.83–1.72

0.337

1.20

0.83–1.72

0.334

E/e’

0.88

0.72–1.09

0.238

0.99

0.81–1.24

0.994

1.00

0.81–1.25

0.977

Enlarged LAA

1.44

0.80–2.57

0.222

1.32

0.74–2.36

0.354

1.31

0.73–2.34

0.369

LVH

1.12

0.87–1.44

0.376

0.96

0.74–1.25

0.777

0.96

0.74–1.25

0.761

MFS

0.92

0.72–1.17

0.494

0.90

0.71–1.15

0.416

0.91

0.71–1.16

0.445

  1. Logistic univariate and multivariate regression analyses with cardiac phenotype (dependent) and Ln-transformed IGFBP7, GDF-15 and P1NP
  2. E/e ‘ > 8 vs <  = 8; GDF-15, growth differentiation factor-15; IGFBP7, insulin grow factor binding protein; P1NP, amino-terminal propeptide of type I procollagen. LAA, left atrial area, enlarged if > 20; LVH: Left ventricular hypertrophy defined as LV mass/BSA > 95 g/m2 for women and > 115 g/m2 for men; MFS, midwall circumference fraction shortening, reduced if MFS < 15%