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Table 5 Best gene–gene interaction models identified by GMDR

From: Association analysis of maternal MTHFR gene polymorphisms and the occurrence of congenital heart disease in offspring

Interaction model

Training bal. acc

Testing bal. acc

P†

CV consistency

rs1801133

0.5487

0.5282

0.0547

9/10

rs2066470-rs1801131

0.5956

0.5929

0.0010

10/10

rs2274976-rs1801133-rs1801131

0.6232

0.5961

0.0010

5/10

  1. GMDR generalized multifactor dimensionality reduction
  2. †Adjusted for maternal education, family income, residence location, abnormal pregnancy history, family consanguineous marriage history, family congenital malformation history, personal lifestyle and habit before pregnancy, exposure history to environmentally hazardous substances as well as medicine history in this pregnancy
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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