Skip to main content

Table 1 Demographic characteristics and echocardiographic data

From: Cardioprotective effect of nicorandil on isoproterenol induced cardiomyopathy in the Mdx mouse model

Mdx mouse groups: Vehicle (n = 10) Nicorandil (n = 10) Isoproterenol (n = 14) Nicorandil + Isoproterenol (n = 14)
Baseline characteristics
Age at study end (weeks) 13.0 ± 0.52 13.4 ± 0.44 13.4 ± 0.47 13.4 ± 0.51
Body weight at study end (g) 25.8 ± 0.53 26.2 ± 0.45 26.4 ± 0.46 25.1 ± 0.45
Echocardiographic measurements
Heart rate (beats per minute)
 Baseline 419 ± 16 472 ± 16 394 ± 19 451 ± 14
 Day 10 501 ± 11* 485 ± 14 454 ± 14* 489 ± 13*
Ejection fraction (%)
 Baseline 71.3 ± 1.8 75.9 ± 2.1 75.2 ± 1.6 75.9 ± 1.6
 Day 10 71.9 ± 2.3 72.6 ± 2.5 68.1 ± 2.6* 74.8 ± 1.6
Fractional shortening (%)
 Baseline 35.3 ± 1.5 39.2 ± 1.8 38.6 ± 1.3 39.2 ± 1.4
 Day 10 36.0 ± 1.8 36.6 ± 2.0 33.4 ± 1.9* 38.2 ± 1.5
Left ventricular end systolic volume (mL)
 Baseline 0.030 ± 0.003 0.027 ± 0.004 0.028 ± 0.003 0.025 ± 0.003
 Day 10 0.040 ± 0.007 0.040 ± 0.005 0.047 ± 0.005* 0.030 ± 0.003*
Left ventricular end diastolic volume (mL)
 Baseline 0.116 ± 0.008 0.190 ± 0.011 0.111 ± 0.005 0.099 ± 0.007
 Day 10 0.119 ± 0.015 0.128 ± 0.011 0.144 ± 0.007* 0.114 ± 0.009
Stroke volume (mL)
 Baseline 0.083 ± 0.006 0.080 ± 0.007 0.083 ± 0.003 0.074 ± 0.005
 Day 10 0.083 ± 0.008 0.093 ± 0.008 0.096 ± 0.005* 0.082 ± 0.007
  1. Echocardiograms were performed at baseline and at 10 days. Isoproterenol induced left ventricular dilation and a mild cardiac injury with a decrease in ejection fraction and fractional shortening and an increased end systolic volume. Nicorandil was protective against left ventricular dilation and isoproterenol-induced injury. (*p < 0.05 vs same group baseline measurement)