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Table 4 Cox regression models for prognostic prediction of the primary endpoint

From: Prognostic relevance of elevated plasma osmolality on admission in acute decompensated heart failure with preserved ejection fraction: insights from PURSUIT-HFpEF registry

  Unadjusted HR (95% CI) P-value Adjusted HR (95% CI) P-value Adjusted HR (95% CI) P-value
Age 5.86 (1.88–19.32) 0.0019 5.67 (1.40–24.73) 0.0143 5.98 (1.53–25.19) 0.0093
Female 1.20 (0.91–1.58) 0.1897 1.19 (0.85–1.68) 0.3120 1.18 (0.85–1.65) 0.3356
AF 0.96 (0.74–1.26) 0.7902 1.15 (0.82–1.62) 0.4163 1.11 (0.79–1.56) 0.5309
HT 0.94 (0.77–1.15) 0.5207 0.87 (0.54–1.48) 0.5952 0.89 (0.55–1.52) 0.6637
Diabetes 0.94 (0.80–1.10) 0.4475 1.18 (0.83–1.67) 0.3447 1.19 (0.84–1.68) 0.3242
hematocrit 0.28 (0.10–0.77) 0.0139 1.08 (0.33–3.41) 0.9028 0.84 (0.27–2.53) 0.7555
eGFR 0.15 (0.07–0.34)  < 0.0001 0.39 (0.12–1.24) 0.1110   
GNRI 0.40 (0.10–1.57) 0.1907 0.66 (0.19–2.36) 0.5257 0.80 (0.23–2.72) 0.7170
Log NT-proBNP 15.04 (1.93–60.70) 0.0139 1.73 (0.46–6.57) 0.4196 2.69 (0.80–8.96) 0.1077
E/e’ 3.29 (1.25–7.84) 0.0168 2.07 (0.61–6.38) 0.2372 1.99 (0.59–6.09) 0.2607
Plasma Osmolality 7.29 (2.25–23.92) 0.0009 3.51 (0.89–17.35) 0.0730 5.47 (1.46–21.56) 0.0113
BUN 6.87 (3.36–13.52)  < 0.0001     
Serum sodium 1.18 (0.39–3.81) 0.7755     
Glucose 1.58 (0.46–4.66) 0.4447     
  1. AF, atrial fibrillation; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; GNRI, Geriatric Nutritional Risk Index, HT, Hypertension; HR, hazard ratio; NT-proBNP, N-terminal pro-B-type natriuretic peptide
  2. Composite endpoint was defined as cardiac mortality or heart failure re-admission