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Table 4 Cox regression models for prognostic prediction of the primary endpoint

From: Prognostic relevance of elevated plasma osmolality on admission in acute decompensated heart failure with preserved ejection fraction: insights from PURSUIT-HFpEF registry

 

Unadjusted HR (95% CI)

P-value

Adjusted HR (95% CI)

P-value

Adjusted HR (95% CI)

P-value

Age

5.86 (1.88–19.32)

0.0019

5.67 (1.40–24.73)

0.0143

5.98 (1.53–25.19)

0.0093

Female

1.20 (0.91–1.58)

0.1897

1.19 (0.85–1.68)

0.3120

1.18 (0.85–1.65)

0.3356

AF

0.96 (0.74–1.26)

0.7902

1.15 (0.82–1.62)

0.4163

1.11 (0.79–1.56)

0.5309

HT

0.94 (0.77–1.15)

0.5207

0.87 (0.54–1.48)

0.5952

0.89 (0.55–1.52)

0.6637

Diabetes

0.94 (0.80–1.10)

0.4475

1.18 (0.83–1.67)

0.3447

1.19 (0.84–1.68)

0.3242

hematocrit

0.28 (0.10–0.77)

0.0139

1.08 (0.33–3.41)

0.9028

0.84 (0.27–2.53)

0.7555

eGFR

0.15 (0.07–0.34)

 < 0.0001

0.39 (0.12–1.24)

0.1110

  

GNRI

0.40 (0.10–1.57)

0.1907

0.66 (0.19–2.36)

0.5257

0.80 (0.23–2.72)

0.7170

Log NT-proBNP

15.04 (1.93–60.70)

0.0139

1.73 (0.46–6.57)

0.4196

2.69 (0.80–8.96)

0.1077

E/e’

3.29 (1.25–7.84)

0.0168

2.07 (0.61–6.38)

0.2372

1.99 (0.59–6.09)

0.2607

Plasma Osmolality

7.29 (2.25–23.92)

0.0009

3.51 (0.89–17.35)

0.0730

5.47 (1.46–21.56)

0.0113

BUN

6.87 (3.36–13.52)

 < 0.0001

    

Serum sodium

1.18 (0.39–3.81)

0.7755

    

Glucose

1.58 (0.46–4.66)

0.4447

    
  1. AF, atrial fibrillation; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; GNRI, Geriatric Nutritional Risk Index, HT, Hypertension; HR, hazard ratio; NT-proBNP, N-terminal pro-B-type natriuretic peptide
  2. Composite endpoint was defined as cardiac mortality or heart failure re-admission