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Table 2 Summary of IVIG dose, ultrasound cardiography and optical coherence tomography data in both Group R and Group N

From: Intimal thickening and disruption of the media occur in the arterial walls of coronary arteries not associated with coronary arterial aneurysms in patients with Kawasaki disease

  Group R (n = 18) Group N (n = 18) p value
Total dose of IVIG (mg/kg) 2600* (0–4200) 2500* (0–4000) p = 0.820
UCG-determined coronary artery diameter Z-score in the acute phase (i.e., time of first CAG) 7.13* (3.65–13.88) 1.81* (-0.18–2.23) p < 0.001
UCG-determined coronary artery diameter Z-score in the convalescent phase (i.e., time of OCT) 0.64* (-0.02–2.11) 0.48* (-0.67–1.60) p = 0.311
Difference in UCG-determined coronary artery diameter Z-scores between acute and convalescent phases 6.26* (2.59–13.9) 1.14* (0.22–2.14) p < 0.001
Maximum intimal thickness (µm) 475* (386–646) 355* (118–552) p = 0.007
Number of abnormal intimal thickening (> 400 µm), n (%) 17 (94) 7 (39) p < 0.001
Intimal cross-sectional area (mm2) 4.12* (2.04–7.86) 2.88* (1.45–5.70) p = 0.029
Disruption of the media, n (%) 18 (100) 12 (67) p = 0.020
  1. IVIG intravenous immunoglobulin, CA coronary artery, CAG coronary angiography, OCT optical coherence tomography, UCG ultrasound cardiography, KD Kawasaki disease
  2. *Median (minimum–maximum)