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Table 2 Association of carotid femoral pulse wave velocity indices with incident AF in the ARIC study, 2011–2017. (n = 3882)

From: Association of arterial stiffness with incident atrial fibrillation: a cohort study

 

PWV quartiles

1st quartile

2nd quartile

3rd quartile

4th quartile

cf PWV (m/s)

 < 9.5

9.5–11.1

11.2–13.2

 > 13.2

# Incident AF cases

181

57

93

96

Person-time (years)

5169

5153

5073

5041

HR (95% CI)

 Model 1

1.60

(1.14, 2.24)

Ref

1.56

(1.12, 2.17)

1.47

(1.05, 2.06)

 Model 2

1.49

(1.06, 2.10)

Ref

1.59

(1.14, 2.10)

1.56

(1.10, 2.19)

 Model 3δ

1.51

(1.07, 2.13)

Ref

1.63

(1.16, 2.28)

1.68

(1.18, 2.38)

 Model 4ς

1.48

(1.05, 2.10)

Ref

1.64

(1.17, 2.30)

1.53

(1.8, 2.18)

 Model 5*

1.51

(1.07, 2.13)

Ref

1.58

(1.12, 2.21)

1.58

(1.11, 2.25)

  1. Abbreviation: baPWV, brachial-ankle pulse wave velocity; cfPWV, carotid-femoral pulse wave velocity, CI; confidence interval; faPWV: femoral-ankle pulse wave velocity; HR, hazard ratio
  2. Model 1: Cox regression model adjusted for sex, age, center, race, education level
  3. Model 2: Cox regression model adjusted for sex, age, center, race, education level, systolic blood pressure, diastolic blood pressure, alcohol use, cigarettes smoking, history of myocardial infarction, history of heart failure, body mass index, aspirin, statin, hypertension, diabetes mellitus, left ventricular ejection fraction and left atrial volume
  4. δModel 3: Model 2 further adjusted for heart failure as a time dependent covariate
  5. ςModel 4: Model 2 further adjusted for NT-pro B-type natriuretic peptide
  6. *Model 5: Fine and Gray competing risks model adjusted for variables in model 2, with death considered as a competing risk