Table 2 Effect of every 50-unit increase in furin on cardiovascular outcomes

Event/no

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

MACE

Low (≤ 117.5)

60/356

1.12 (0.80, 1.56)

0.519

1.18 (0.84, 1.66)

0.338

1.41 (0.91, 2.17)

0.125

Medium (117.5–200)

57/374

Ref

Ref

Ref

High (≥ 200)

64/370

1.04 (0.74, 1.46)

0.824

1.08 (0.77, 1.53)

0.655

1.20 (0.76, 1.90)

0.433

50-pg/mL increase

181/1100

1.01 (1.00, 1.03)

0.084

1.02 (1.00, 1.03)

0.030

1.01 (0.96, 1.06)

0.807

CV death

Low (≤ 117.5)

46/356

1.17 (0.77, 1.78)

0.465

1.21 (0.79, 1.86)

0.376

1.29 (0.75, 2.22)

0.350

Medium (117.5–200)

42/374

Ref

Ref

Ref

High (≥ 200)

45/325

1.10 (0.72, 1.67)

0.661

1.20 (0.78, 1.84)

0.410

1.02 (0.57, 1.83)

0.939

50-pg/mL increase

133/1100

1.01 (1.00, 1.03)

0.078

1.02 (1.00, 1.04)

0.013

0.99 (0.92, 1.06)

0.709

Non-fatal MI

Low (≤ 117.5)

7/356

1.16 (0.41–3.30)

0.786

1.20 (0.42, 3.45)

0.734

1.68 (0.36, 7.90)

0.509

Medium (117.5–200)

7/374

Ref

Ref

Ref

High (≥ 200)

12/370

1.67 (0.66, 4.25)

0.280

1.73 (0.68, 4.45)

0.253

5.12 (1.24, 21.2)

0.024

50-pg/mL increase

26/1100

1.02 (0.98, 1.07)

0.394

1.02 (0.98, 1.07)

0.316

1.09 (1.01, 1.17)

0.022

Non-fatal stroke

Low (≤ 117.5)

7/356

1.04 (0.38, 2.86)

0.945

0.99 (0.35, 2.74)

0.976

1.34 (0.41, 4.40)

0.625

Medium (117.5–200)

8/374

Ref

Ref

Ref

High (≥ 200)

7/370

0.88 (0.32, 2.43)

0.806

0.83 (0.29, 2.41)

0.731

0.62 (0.15, 2.65)

0.521

50-pg unit increase

22/1100

0.92 (0.76, 1.11)

0.389

0.91 (0.74, 1.12)

0.358

0.85 (0.64, 1.14)

0.277

Hospitalised HF

Low (≤ 117.5)

10/356

1.05 (0.44, 2.53)

0.908

1.08 (0.45, 2.60)

0.860

1.85 (0.53, 6.39)

0.333

Medium (117.5–200)

10/374

Ref

Ref

Ref

High (≥ 200)

7/370

0.71 (0.27, 1.85)

0.479

0.74 (0.28, 1.94)

0.540

1.71 (0.48,6.10)

0.405

50-pg/mL increase

27/1100

0.99 (0.91, 1.09)

0.862

0.99 (0.90, 1.09)

0.876

1.03 (0.94,1.14)

0.490

Non-CV death

Low (≤ 117.5)

16/356

1.68 (0.76, 3.71)

0.197

1.88 (0.85, 4.15)

0.121

1.70 (0.60, 4.79)

0.316

Medium (117.5–200)

10/374

Ref

Ref

Ref

High (≥ 200)

11/370

1.11 (0.47, 2.61)

0.817

1.15 (0.49, 2.71)

0.097

0.58 (0.14, 2.39)

0.449

50-pg/mL increase

37/1100

1.01 (0.99, 1.04)

0.305

1.02 (1.00, 1.05)

0.093

0.94 (0.75, 1.17)

0.561

All death

Low (≤ 117.5)

62/356

1.28 (0.89, 1.85)

0.191

1.36 (0.93, 1.98)

0.112

1.37 (0.85, 2.22)

0.195

Medium (117.5–200)

52/374

Ref

Ref

Ref

High (≥ 200)

56/370

1.11 (0.76, 1.62)

0.600

1.21 (0.83, 1.78)

0.327

0.94 (0.55, 1.59)

0.804

50-pg/mL increase

170/1100

1.02 (1.00,1.03)

0.025

1.02 (1.01, 1.04)

0.002

0.98 (0.92, 1.05)

0.548