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Table 1 Baseline characteristics of all participants

From: Effects of empagliflozin in different phases of diabetes mellitus-related cardiomyopathy: a prospective observational study

 

EMPA group (n = 35)

Control group (n = 20)

p value

Backgrounds

Age (years old)

66.4 ± 10.0

65.7 ± 10.5

0.794

Male gender (%)

26 (74.3)

15 (75.0)

0.954

Body mass index (kg/m2)

24.2 ± 4.4

24.5 ± 4.5

0.755

NYHA class

3.1 ± 0.8

2.8 ± 0.8

0.208

Systolic blood pressure (mmHg)

122.8 ± 16.1

121.8 ± 19.0

0.828

Diastolic blood pressure (mmHg)

77.6 ± 8.6

74.7 ± 6.4

0.195

Heart rate (bpm)

79.2 ± 10.4

80.9 ± 11.1

0.583

Hypertension (%)

29 (82.9)

16 (80.0)

0.796

Dyslipidemia (%)

29 (82.9)

15 (75.0)

0.493

T2DM duration (months)

48 (24–103)

44 (31–47)

0.895

Hemoglobin (g/dl)

14.1 ± 2.4

13.4 ± 3.2

0.381

HbA1c (%)

8.2 ± 1.5

7.9 ± 0.7

0.339

Sodium (mEq/l)

139.1 ± 3.2

139.8 ± 2.0

0.375

eGFR (ml/min/1.73m2)

73.7 (64.7–77.8)

70.2 (57.9–77.9)

0.489

BNP (pg/ml)

498 (304–709)

525 (314–811)

0.766

UCG characteristics

LAD (mm)

44 (39–46)

44 (40–45)

0.916

LVDd (mm)

51 (48–54)

50 (48–55)

0.435

LVEF (%)

51.8 ± 10.5

52.5 ± 10.7

0.827

LVGLS (absolute value) (%)

7.2 ± 2.8

7.6 ± 3.0

0.642

E/e′

12.9 ± 5.0

12.9 ± 5.1

0.962

CMR characteristics

LVEDV index (ml/m2)

61.5 ± 17.1

60.5 ± 19.7

0.836

LVM index (g/m2)

49.6 ± 11.7

51.6 ± 14.3

0.570

Medications

β blocker (%)

18 (51.4)

11 (55.0)

0.803

ACEi (%)

4 (11.4)

4 (20.0)

0.395

ARB (%)

26 (74.3)

14 (70.0)

0.737

ARNI (%)

0 (0.0)

0 (0.0)

Loop diuretics (%)

28 (80.0)

18 (90.0)

0.479

MRA (%)

5 (14.3)

4 (20.0)

0.590

Tolvaptan (%)

0 (0.0)

2 (10.0)

0.163

SGLT2i (%)

35 (100)

0 (0.0)

Metformin (%)

12 (34.3)

4 (20.0)

0.250

DPP4i (%)

28 (80.0)

17 (85.0)

0.493

GLP-1 agonist (%)

2 (5.7)

0 (0.0)

0.160

Thiazolidine (%)

2 (5.7)

0 (0.0)

0.160

Sulfonylurea (%)

2 (5.7)

1 (5.0)

0.913

Grinide (%)

0 (0.0)

0 (0.0)

α-GI (%)

6 (17.1)

4 (20.0)

0.796

  1. Data are means ± SD for normally distributed data and medians and interquartile ranges for non-normally distributed data, or n (%). All statistical tests were 2-tailed, and p < 0.05 was considered significant (*)
  2. NYHA, New York Heart Association; T2DM, type 2 diabetes mellitus; HbA1c, glycated hemoglobin; eGFR, estimated glomerular filtration rate; BNP, brain natriuretic peptide; UCG, ultrasonic echocardiography; LAD, left atrial dimension; LVDd, left ventricular end-diastolic dimension; LVEF, left ventricular ejection fraction; LVGLS, left ventricular global longitudinal strain; E/e', ratio of early diastolic mitral inflow velocity to early diastolic mitral annular velocity; CMR, cardiac magnetic resonance; LVEDV, left ventricular end-diastolic volume; LVM, left ventricular mass; ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin II receptor blocker; ARNI, angiotensin receptor neprilysin inhibitor; MRA, mineralocorticoid receptorantagonist; SGLT2i, sodium-glucose co-transporter 2 inhibitor; DPP4i, dipeptidyl peptidase-4 inhibitor; GLP-1, glucagon like peptide-1; α-GI, alpha-glucosidase inhibitor