Table 1 Overview of all features stored in the database

Baseline

(2007-Feb 2018)

Consult

(-) Presence and characteristics of cardiac symptoms (chest pain, dyspnoea, fatigue, palpitations, collapse, heart murmurs)

(-) Anthropometrics (height, weight, hip circumference, blood pressure, heart rate, heart and breathing sounds, pulse, palpation)

Intake

(-) Behavioural cardiovascular risk factors (smoking, alcohol use)

(-) Comorbidities (diabetes mellitus, hypertension, dyslipidaemia)

(-) Family history of cardiovascular disease (atherosclerosis, sudden death, cardiomyopathy, arrhythmia)

Lab

(-) Lipids (total, high density, and low density cholesterol, triglycerides)

(-) Potassium, sodium, haemoglobin, glucose

(-) Glomerular filtration rate

(-) Lipoprotein A, brain natriuretic protein, thyroid stimulation hormone

TTE

(-) M-mode (dimensions of aorta and left heart chambers)

(-) Two-dimensional (evaluation of function and shape of all heart chambers and valves)

(-) Colour Doppler (valve insufficiencies and septum defects)

(-) Spectral Doppler (left ventricular diastolic function and gradients over valves)

(-) Intima Media Thickness (left and right, anterior and posterior)

ECG

(-) Duration of defined ECG intervals and complexes (RR, PR, QRS, QT)

(-) ST depression, elevation, negative T-top, QRS axis

(-) Dilatation of left and right atrium, intraventricular conduction delay, left ventricular hypertrophy

Stress ECG

(-) Protocol, device, target heart rate, use of β-blocker before exercise test

(-) ECG characteristics, blood pressure and heart rate before and during exercise test

(-) Duration and load of exercise test, exercise tolerance, reason to stop exercise test

(-) Arrhythmia or angina symptoms during exercise test, left ventricular hypertrophy

Decursus

(-) Cardiologist summary of visit (free text)

Medication

(-) Cardiovascular medication use grouped by researchers

(-) Date medication was started and date it was ended when applicable

Diagnosis

(-) Cardiovascular diagnosis defined by researchers

(-) Cardiovascular risk factor diagnosis defined by researchers

(-) Date of diagnosis

Follow-up

(2007—Feb 2018)

Consult, Intake, Lab, TTE, ECG, Stress ECG and Decursus as described for baseline

External procedures

(-) External procedure performed and location where it was performed

(-) External procedure grouped by researchers

(-) Date of appointment

Record linkage (2019)

All-cause mortality

Educational level

Ethnicity

Personal income

Cause-specific mortality