Table 1 Participant characteristics
From: Genome-wide analysis of DNA methylation and risk of cardiovascular disease in a Chinese population
Variables | Discovery set | Replication set | ||||
|---|---|---|---|---|---|---|
Cases (n = 83) | Controls (n = 83) | p | Cases (n = 38) | Controls (n = 38) | p | |
Basic characteristic | ||||||
 Age | 62 (8) | 62 (8) | 0.986 | 61 (9) | 61 (9) | 1 |
 Male | 47 (56.6) | 47 (56.6) | 1 | 20 (52.6) | 20 (52.6) | 1 |
 Ethnicity (han) | 78 (94.0) | 78 (94.0) | 1 | 37 (97.4) | 37 (97.4) | 1 |
 Current smoker | 26 (31.3) | 26 (31.3) | 1 | 11 (28.9) | 11(28.9) | 1 |
 Smoking indexa | 820 (490, 940) | 545 (305, 860) | 0.180 | 570 (320, 860) | 620 (480, 880) | 0.804 |
 Drinker | 11 (13.3) | 11 (13.3) | 1 | 4 (10.5) | 4 (10.5) | 1 |
 BMI | 25.5 (4.0) | 25.5 (4.0) | 0.956 | 26.0 (3.5) | 26.0 (3.5) | 0.983 |
Diagnosis | ||||||
 Hyperlipidemia | 19 (22.9) | 9 (10.8) | 0.038 | 5 (13.2) | 6 (15.8) | 0.744 |
 Hypertension | 79 (95.2) | 76 (91.6) | 0.349 | 34 (89.5) | 33 (86.8) | 0.723 |
 Diabetes | 32 (38.6) | 31 (37.3) | 0.873 | 12 (31.6) | 16 (42.1) | 0.342 |
 Family history of CHD | 6 (7.2) | 3 (3.6) | 0.304 | 0 (0.0) | 2 (5.3) | 0.152 |
Clinical exams | ||||||
 Systolic pressure | 164 (21) | 163 (20) | 0.553 | 165 (22) | 158 (21) | 0.137 |
 Diastolic pressure | 95 (13) | 91 (12) | 0.019 | 96 (13) | 91 (13) | 0.150 |
 HbA1c (%) | 4.9 (4.6, 5.3) | 5.0 (4.6, 5.4) | 0.639 | 4.8 (4.6, 5.3) | 4.9 (4.7, 5.2) | 0.714 |
 hsCRP (mg/L) | 0.8 (0.5, 2.1) | 1.1 (0.5, 2.4) | 0.317 | 1.2 (0.7, 2.4) | 1.1 (0.6, 2.3) | 0.373 |
 HDL-C (mmol/L) | 0.8 (0.7, 1.0) | 0.8 (0.7, 1.1) | 0.981 | 0.9 (0.7, 1.1) | 0.9 (0.7, 1.0) | 0.593 |
 LDL-C(mmol/L) | 2.6 (2.1, 3.2) | 2.4 (2.0, 3.0) | 0.188 | 2.6 (2.1, 3.0) | 2.6 (2.2, 3.3) | 0.461 |
 TG (mmol/L) | 1.3 (0.9, 1.9) | 1.1 (0.8, 1.6) | 0.223 | 1.3 (1.0, 1.7) | 1.5 (0.9, 2.0) | 0.262 |
 TC (mmol/L) | 4.3 (3.6, 5.0) | 4.2 (3.5, 5.1) | 0.549 | 4.2 (3.7, 5.0) | 4.4 (3.7, 5.5) | 0.424 |
Events during follow up | ||||||
 CVD deathb | 18 (21.7) | 0 | NA | 5 (13.2) | 0 | NA |
 CVD admissionc | 65 (78.3) | 0 | NA | 33 (86.8) | 0 | NA |
  AMI | 24 (28.9) | 0 | NA | 4 (10.5) | 0 | NA |
  Ischemic stroke | 41 (49.4) | 0 | NA | 29 (76.3) | 0 | NA |