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Fig. 6 | BMC Cardiovascular Disorders

Fig. 6

From: Hsa_circ_0004831 downregulation is partially responsible for atorvastatinalleviated human umbilical vein endothelial cell injuries induced by ox-LDL through targeting the miR-182-5p/CXCL12 axis

Fig. 6

CXCL12 was a target of miR-182-5p. a The binding sites between miR-182-5p and CXCL12 3′UTR were analyzed by starbase. b, c The interaction between miR-182-5p and CXCL12 was verified by dual-luciferase reporter assay and biotin RNA pull-down assay. d The efficiency of miR-182-5p inhibitor was checked using qPCR. e, f The expression of CXCL12 in HUVECs with miR-182-5p overexpression or inhibition was detected using qPCR and western blot. g, h The expression of CXCL12 in ox-LDL-treated HUVECs was detected by qPCR and western blot. i, j The expression of CXCL12 in ox-LDL-treated HUVECs with the addition of ATV was detected by qPCR and western blot. **P < 0.01, ***P < 0.001

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BMC Cardiovascular Disorders

ISSN: 1471-2261

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