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Fig. 4 | BMC Cardiovascular Disorders

Fig. 4

From: Hsa_circ_0004831 downregulation is partially responsible for atorvastatinalleviated human umbilical vein endothelial cell injuries induced by ox-LDL through targeting the miR-182-5p/CXCL12 axis

Fig. 4

MiR-182-5p was a target of hsa_circ_0004831. a MiR-182-5p and miR-377-3p were predicted as targets of hsa_circ_0004831 both by circular RNA interactome and starbase. b Biotin RNA pull-down assay was performed to screen miR-182-5p and miR-377-3p. c The binding sites between hsa_circ_0004831 and miR-182-5p. d The distribution of hsa_circ_0004831 in the cytoplasm or nucleus was determined by subcellular distribution assay. e, f The relationship between hsa_circ_0004831 and miR-182-5p was validated by dual-luciferase reporter assay and RIP assay. g, h The effect of hsa_circ_0004831 knockdown or overexpression on the expression of miR-182-5p. i The expression of miR-182-5p in HUVECs treated with different concentrations of ox-LDL. j The expression of miR-182-5p in ox-LDL-treated HUVECs with the addition of ATV. **P < 0.01, ***P < 0.001

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BMC Cardiovascular Disorders

ISSN: 1471-2261

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