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Fig. 3 | BMC Cardiovascular Disorders

Fig. 3

From: Hsa_circ_0004831 downregulation is partially responsible for atorvastatinalleviated human umbilical vein endothelial cell injuries induced by ox-LDL through targeting the miR-182-5p/CXCL12 axis

Fig. 3

ATV alleviated ox-LDL-induced HUVEC injuries by suppressing the expression of hsa_circ_0004831. a, b The efficiency of hsa_circ_0004831 interference or hsa_circ_0004831 overexpression. Ox-LDL-treated HUVECs with the addition of ATV were transfected with si-circRNA#1 or circRNA, with si-NC or pCD-ciR as the control. Then, c the expression of hsa_circ_0004831 in these groups. d Cell viability was checked using CCK-8 assay. e, f Cell apoptosis and cell cycle were analyzed in these cells using flow cytometry assay. g, h The levels of MDA and SOD. i, j The release of IL-6 and IL-1β. *P < 0.05, **P < 0.01, ***P < 0.001

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BMC Cardiovascular Disorders

ISSN: 1471-2261

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