Table 1 Patient baseline characteristics

Age, years^a

75.4 ± 0.5

Male Sex, n (%)

215 (65.0)

Risk factors, n (%)

 Hypertension

283 (85.5)

 Diabetes mellitus

103 (31.1)

 Smoker (current or past)

98 (29.6)

 Dyslipidemia

158 (47.7)

Cardiovascular history, n (%)

 Heart failure

91 (27.5)

 Coronary artery disease

110 (33.2)

 Myocardial infarction

35 (10.6)

 Previous deep vein thrombosis/pulmonary embolism

34 (10.3)

Previous ischemic stroke, n (%)

127 (38.4)

Previous hemorrhagic event, n (%)

304 (91.8)

 Hemorrhagic stroke

100 (30.2)

 Subarachnoid hemorrhage

10 (3.0)

 Epidural/subdural hematoma

33 (10.0)

 Ischemic stroke with hemorrhagic transformation

19 (5.7)

 Gastro-intestinal bleeding

90 (27.2)

 Spontaneous hematoma

40 (12.1)

Other co-morbidities

 Cirrhosis, n (%)

13 (3.9)

 Chronic obstructive pulmonary disease, n (%)

43 (13.0)

 Thyroid dysfunction, n (%)

69 (20.8)

 Creatinine at admission (µmol/l)^b

99 [80–129]

 Creatinine clearance at admission, mL/min^b

62 [43–78]

 Hemoglobin at admission (g/dl)^b

13 [11.6–14.2]

CHA₂DS₂-VASc score^a

4.5 ± 0.1

HAS-BLED score^a

3.1 ± 0.1