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Table 2 Per-patient Lifetime Costs under the Main Examined Medication Scenarios, by Resource Type and Healthcare Setting

From: Burden of oral anticoagulation in embolic stroke of undetermined source without atrial fibrillation

  Aspirin Dabigatran
150 mg
Rivaroxaban
20 mg
Δ Dabigatran vs. Aspirin Δ Rivaroxaban vs. Aspirin
United States Ischaemic Strokes $8,477.30 $5,934.11 $5,934.11 − $2,543.19 − $2,543.19
Bleeding Events $31,867.78 $37,443.42 $41,953.51 $5,575.64 $10,085.73
Prescriptions $259.38 $23,994.99 $24,976.10 $23,735.61 $24,716.72
TOTAL $40,604.46 $67,372.52 $72,863.72 $26,768.06 $32,259.26
United Kingdom Ischaemic Strokes £4,953.06 £3,467.14 £3,467.14 − £1,485.92 − £1,485.92
Bleeding Events £2,619.19 £2,565.92 £3,181.65 − £53.27 £562.46
Prescriptions £123.19 £7,615.42 £8,064.49 £7,492.23 £7,941.30
TOTAL £7,695.44 £13,648.49 £14,713.29 £5,953.04 £7,017.84
Netherlands Ischaemic Strokes €1,141.41 €798.99 €798.99 − €342.42 − €342.42
Bleeding Events €3,342.24 €3,934.81 €4,404.05 €592.57 €1,061.81
Prescriptions €3,173.39 €9,605.93 €9,821.69 €6,432.54 €6,648.30
TOTAL €7,657.04 €14,339.73 €15,024.73 €6,682.69 €7,367.69
Spain Ischaemic Strokes €2,377.23 €1,664.06 €1,664.06 − €713.17 − €713.17
Bleeding Events €4,640.58 €5,299.34 €6,029.50 €658.76 €1,388.92
Prescriptions €986.27 €5,974.15 €9,689.00 €4,987.88 €8,702.73
TOTAL €8,004.08 €12,937.55 €17,382.57 €4,933.47 €9,378.48
Australia Ischaemic Strokes AUD$7,141.27 AUD$4,998.89 AUD$4,998.89 − AUD$2,142.38 − AUD$2,142.38
Bleeding Events AUD$6,328.85 AUD$6,831.18 AUD$8,016.72 AUD$502.33 AUD$1,687.87
Prescriptions AUD$554.31 AUD$7,547.08 AUD$7,548.11 AUD$6,992.77 AUD$6,993.80
TOTAL AUD$14,024.43 AUD$19,377.15 AUD$20,563.72 AUD$5,352.72 AUD$6,539.29
  1. Please note the relative reduction of 30% was assumed equal for dabigatran and rivaroxaban. Note that results would remain cost-additive even if a 100% reduction in ischaemic strokes vs. aspirin was assumed with the DOACs