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Table 2 Per-patient Lifetime Costs under the Main Examined Medication Scenarios, by Resource Type and Healthcare Setting

From: Burden of oral anticoagulation in embolic stroke of undetermined source without atrial fibrillation

 

Aspirin

Dabigatran

150 mg

Rivaroxaban

20 mg

Δ Dabigatran vs. Aspirin

Δ Rivaroxaban vs. Aspirin

United States

Ischaemic Strokes

$8,477.30

$5,934.11

$5,934.11

− $2,543.19

− $2,543.19

Bleeding Events

$31,867.78

$37,443.42

$41,953.51

$5,575.64

$10,085.73

Prescriptions

$259.38

$23,994.99

$24,976.10

$23,735.61

$24,716.72

TOTAL

$40,604.46

$67,372.52

$72,863.72

$26,768.06

$32,259.26

United Kingdom

Ischaemic Strokes

£4,953.06

£3,467.14

£3,467.14

− £1,485.92

− £1,485.92

Bleeding Events

£2,619.19

£2,565.92

£3,181.65

− £53.27

£562.46

Prescriptions

£123.19

£7,615.42

£8,064.49

£7,492.23

£7,941.30

TOTAL

£7,695.44

£13,648.49

£14,713.29

£5,953.04

£7,017.84

Netherlands

Ischaemic Strokes

€1,141.41

€798.99

€798.99

− €342.42

− €342.42

Bleeding Events

€3,342.24

€3,934.81

€4,404.05

€592.57

€1,061.81

Prescriptions

€3,173.39

€9,605.93

€9,821.69

€6,432.54

€6,648.30

TOTAL

€7,657.04

€14,339.73

€15,024.73

€6,682.69

€7,367.69

Spain

Ischaemic Strokes

€2,377.23

€1,664.06

€1,664.06

− €713.17

− €713.17

Bleeding Events

€4,640.58

€5,299.34

€6,029.50

€658.76

€1,388.92

Prescriptions

€986.27

€5,974.15

€9,689.00

€4,987.88

€8,702.73

TOTAL

€8,004.08

€12,937.55

€17,382.57

€4,933.47

€9,378.48

Australia

Ischaemic Strokes

AUD$7,141.27

AUD$4,998.89

AUD$4,998.89

− AUD$2,142.38

− AUD$2,142.38

Bleeding Events

AUD$6,328.85

AUD$6,831.18

AUD$8,016.72

AUD$502.33

AUD$1,687.87

Prescriptions

AUD$554.31

AUD$7,547.08

AUD$7,548.11

AUD$6,992.77

AUD$6,993.80

TOTAL

AUD$14,024.43

AUD$19,377.15

AUD$20,563.72

AUD$5,352.72

AUD$6,539.29

  1. Please note the relative reduction of 30% was assumed equal for dabigatran and rivaroxaban. Note that results would remain cost-additive even if a 100% reduction in ischaemic strokes vs. aspirin was assumed with the DOACs