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Table 2 Hazard ratios and 95%CIs for death and cardiovascular events associated with age at menopause (four groups) in women

From: Combined effect of menopause and cardiovascular risk factors on death and cardiovascular disease: a cohort study

Age at menopause Women Events Woman-years Events per 1000 person-years Adjusted HR (95% CI) P valuea
Death
 < 45 years old 160 10 4107 2.4 1.32 (0.63, 2.76) 0.46
 45–49 years old 790 64 19,880 3.2 1.99 (1.24, 3.21) 0.005
 50–51 years old 506 25 13,088 1.9 1.00 (reference) 0.001
 > 51 years old 648 25 16,767 1.5 0.79 (0.45, 1.38) 0.40
Cardiovascular disease
 < 45 years old 160 23 3893 5.9 1.46 (0.89, 2.41) 0.14
 45–49 years old 790 68 19,200 3.5 1.18 (0.81, 1.72) 0.39
 50–51 years old 506 49 12,611 3.9 1.00 (reference) 0.22
 > 51 years old 648 56 16,269 3.4 0.91 (0.62, 1.34) 0.63
Fatal cardiovascular disease
 < 45 years old 160 3 4101 0.7 0.86 (0.24, 3.09) 0.82
 45–49 years old 790 14 19,802 0.7 1.19 (0.53, 2.69) 0.67
 50–51 years old 506 11 13,038 0.8 1.00 (reference) 0.18
 > 51 years old 648 5 16,747 0.3 0.38 (0.13, 1.09) 0.07
Ischemic cardiovascular disease
 < 45 years old 160 21 3917 5.4 1.56 (0.92, 2.65) 0.10
 45–49 years old 790 62 19,230 3.2 1.28 (0.86, 1.91) 0.23
 50–51 years old 506 42 12,697 3.3 1.00 (reference) 0.19
 > 51 years old 648 51 16,316 3.1 0.97 (0.65, 1.47) 0.90
Coronary heart disease
 < 45 years old 160 11 4053 2.7 1.32 (0.65, 2.70) 0.44
 45–49 years old 790 27 19,692 1.4 0.82 (0.47, 1.44) 0.50
 50–51 years old 506 25 12,927 1.9 1.00 (reference) 0.25
 > 51 years old 648 21 16,652 1.3 0.65 (0.36, 1.17) 0.15
Stroke
 < 45 years old 160 14 3939 3.6 1.72 (0.90, 3.31) 0.10
 45–49 years old 790 43 19,402 2.2 1.50 (0.91, 2.46) 0.11
 50–51 years old 506 26 12,804 2.0 1.00 (reference) 0.19
 > 51 years old 648 34 16,397 2.1 1.06 (0.64, 1.78) 0.82
Ischemic stroke
 < 45 years old 160 12 3962 3.0 2.16 (1.04, 4.51) 0.04
 45–49 years old 790 38 19,411 2.0 2.05 (1.15, 3.63) 0.01
 50–51 years old 506 18 12,857 1.4 1.00 (reference) 0.05
 > 51 years old 648 30 16,431 1.8 1.37 (0.76, 2.47) 0.29
Hemorrhagic stroke
 < 45 years old 160 2 4084 0.5 0.71 (0.15, 3.35) 0.67
 45–49 years old 790 7 19,869 0.4 0.66 (0.24, 1.82) 0.42
 50–51 years old 506 9 13,032 0.7 1.00 (reference) 0.37
 > 51 years old 648 4 16,733 0.2 0.34 (0.10, 1.12) 0.08
  1. Model adjusted for: time-varying covariates including menopause, use of oral estrogen owing to menopause, body mass index, smoking, systolic blood pressure, diastolic blood pressure, fasting glucose, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, and triglyceride; baseline covariates including age, family history of cardiovascular disease, and white blood cell count
  2. HR hazard ratio, CI confidence interval
  3. aP values derived from Cox regression model for non-proportional hazards