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Table 2 Hazard ratios and 95%CIs for death and cardiovascular events associated with age at menopause (four groups) in women

From: Combined effect of menopause and cardiovascular risk factors on death and cardiovascular disease: a cohort study

Age at menopause

Women

Events

Woman-years

Events per 1000 person-years

Adjusted HR (95% CI)

P valuea

Death

 < 45 years old

160

10

4107

2.4

1.32 (0.63, 2.76)

0.46

 45–49 years old

790

64

19,880

3.2

1.99 (1.24, 3.21)

0.005

 50–51 years old

506

25

13,088

1.9

1.00 (reference)

0.001

 > 51 years old

648

25

16,767

1.5

0.79 (0.45, 1.38)

0.40

Cardiovascular disease

 < 45 years old

160

23

3893

5.9

1.46 (0.89, 2.41)

0.14

 45–49 years old

790

68

19,200

3.5

1.18 (0.81, 1.72)

0.39

 50–51 years old

506

49

12,611

3.9

1.00 (reference)

0.22

 > 51 years old

648

56

16,269

3.4

0.91 (0.62, 1.34)

0.63

Fatal cardiovascular disease

 < 45 years old

160

3

4101

0.7

0.86 (0.24, 3.09)

0.82

 45–49 years old

790

14

19,802

0.7

1.19 (0.53, 2.69)

0.67

 50–51 years old

506

11

13,038

0.8

1.00 (reference)

0.18

 > 51 years old

648

5

16,747

0.3

0.38 (0.13, 1.09)

0.07

Ischemic cardiovascular disease

 < 45 years old

160

21

3917

5.4

1.56 (0.92, 2.65)

0.10

 45–49 years old

790

62

19,230

3.2

1.28 (0.86, 1.91)

0.23

 50–51 years old

506

42

12,697

3.3

1.00 (reference)

0.19

 > 51 years old

648

51

16,316

3.1

0.97 (0.65, 1.47)

0.90

Coronary heart disease

 < 45 years old

160

11

4053

2.7

1.32 (0.65, 2.70)

0.44

 45–49 years old

790

27

19,692

1.4

0.82 (0.47, 1.44)

0.50

 50–51 years old

506

25

12,927

1.9

1.00 (reference)

0.25

 > 51 years old

648

21

16,652

1.3

0.65 (0.36, 1.17)

0.15

Stroke

 < 45 years old

160

14

3939

3.6

1.72 (0.90, 3.31)

0.10

 45–49 years old

790

43

19,402

2.2

1.50 (0.91, 2.46)

0.11

 50–51 years old

506

26

12,804

2.0

1.00 (reference)

0.19

 > 51 years old

648

34

16,397

2.1

1.06 (0.64, 1.78)

0.82

Ischemic stroke

 < 45 years old

160

12

3962

3.0

2.16 (1.04, 4.51)

0.04

 45–49 years old

790

38

19,411

2.0

2.05 (1.15, 3.63)

0.01

 50–51 years old

506

18

12,857

1.4

1.00 (reference)

0.05

 > 51 years old

648

30

16,431

1.8

1.37 (0.76, 2.47)

0.29

Hemorrhagic stroke

 < 45 years old

160

2

4084

0.5

0.71 (0.15, 3.35)

0.67

 45–49 years old

790

7

19,869

0.4

0.66 (0.24, 1.82)

0.42

 50–51 years old

506

9

13,032

0.7

1.00 (reference)

0.37

 > 51 years old

648

4

16,733

0.2

0.34 (0.10, 1.12)

0.08

  1. Model adjusted for: time-varying covariates including menopause, use of oral estrogen owing to menopause, body mass index, smoking, systolic blood pressure, diastolic blood pressure, fasting glucose, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, and triglyceride; baseline covariates including age, family history of cardiovascular disease, and white blood cell count
  2. HR hazard ratio, CI confidence interval
  3. aP values derived from Cox regression model for non-proportional hazards
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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