Association of ACE2 variant rs4646188 with the risks of atrial fibrillation and cardioembolic stroke in Uygur patients with type 2 diabetes

Liu, Cheng; Pei, Jingxian; Lai, Yanxian; Guan, Tianwang; Zeyaweiding, Abudurexiti; Maimaiti, Tutiguli; Zhao, Haiyan; Shen, Yan

doi:10.1186/s12872-021-01915-9

Table 1 Association between ACE2 SNPs and new-onset AF in diabetic participants

From: Association of ACE2 variant rs4646188 with the risks of atrial fibrillation and cardioembolic stroke in Uygur patients with type 2 diabetes

ACE2 SNPs	Total				Non-T2D subgroup				T2D subgroup
ACE2 SNPs	Non-AF (N/%)	AF (N/%)	RR (95%CI)*	P value*	Non-AF (N/%)	AF (N/%)	RR (95%CI)^#	P value ^#	Non-AF (N/%)	AF (N/%)	RR (95%CI)^#	P value ^#
rs1978124
CC	277 (60.3)	54 (61.4)	1.00		158 (65.8)	16 (50.0)	1.00		119 (54.3)	38 (67.9)	1.00
TT + CT	182 (39.7)	34 (38.6)	0.76 (0.42–1.38)	0.364	82 (34.2)	16 (50.0)	1.34 (0.43–4.12)	0.616	100 (45.7)	18 (32.1)	0.66 (0.27–1.63)	0.369
rs2048683
GG	329 (71.7)	64 (72.7)	1.00		196 (81.7)	26 (81.2)	1.00		133 (60.7)	38 (67.9)	1.00
TT + GT	130 (28.3)	24 (27.3)	0.66 (0.34–1.26)	0.207	44 (18.3)	6 (18.8)	0.30 (0.06–1.56)	0.151	86 (39.3)	18 (32.1)	1.07 (0.39–2.97)	0.896
rs2074192
CC	190 (41.4)	50 (56.8)	2.55 (1.35–4.80)	0.004	94 (39.2)	10 (31.3)	0.44 (0.13–1.51)	0.191	96 (48.3)	40 (71.4)	3.22 (1.26–8.24)	0.015
TT + CT	269 (58.6)	38 (43.2)	1.00		146 (60.8)	22 (60.7)	1.00		123 (56.2)	16 (28.6)	1.00
rs233575
CC + CT	142 (30.9)	28 (31.8)	0.99 (0.53–1.86)	0.983	48 (20.0)	10 (31.3)	1.59 (0.54–4.68)	0.397	94 (42.9)	18 (32.1)	0.70 (0.18–2.66)	0.598
TT	317 (69.1)	60 (68.2)	1.00		192 (80.0)	22 (60.7)	1.00		125 (57.1)	38 (67.9)	1.00
rs4240157
CC + CT	140 (30.5)	48 (54.5)	2.26 (1.27–4.04)	0.006	54 (22.5)	10 (31.3)	0.97 (0.31–3.06)	0.960	86 (39.3)	38 (67.9)	3.38 (1.15–9.98)	0.027
TT	319 (69.5)	40 (45.5)	1.00		186 (77.5)	22 (60.7)	1.00		133 (60.7)	18 (32.1)	1.00
rs4646156
AA + AT	134 (29.2)	24 (27.3)	0.61 (0.32–1.16)	0.134	48 (20.0)	6 (18.8)	0.29 (0.06–1.47)	0.134	86 (39.3)	18 (32.1)	0.79 (0.28–2.24)	0.659
TT	325 (70.8)	64 (72.7)	1.00		192 (80.0)	26 (81.2)	1.00		133 (60.7)	38 (67.9)	1.00
rs4646188
CC + CT	152 (33.1)	14 (15.9)	1.00		88 (36.7)	8 (25.0)	1.00		64 (29.2)	6 (10.7)	1.00
TT	307 (66.9)	74 (84.1)	2.37 (1.16–4.86)	0.018	152 (63.3)	24 (75.0)	1.17 (0.28–4.92)	0.827	155 (70.8)	50 (89.3)	3.03 (1.06–8.66)	0.039
rs879922
CC + CG	244 (53.2)	60 (68.2)	0.95 (0.52–1.75)	0.878	114 (47.5)	14 (43.8)	0.92 (0.35–2.37)	0.857	130 (59.4)	46 (82.1)	1.03 (0.35–3.00)	0.957
GG	215 (46.8)	28 (31.8)	1.00		126 (52.5)	18 (56.3)	1.00		89 (40.6)	10 (17.9)	1.00

* Model 1: after adjustment for age, HT, T2D, LDL-C and LAD
# Model 2: It is the same as Model 1 with exception of T2D

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