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Table 1 Association between ACE2 SNPs and new-onset AF in diabetic participants

From: Association of ACE2 variant rs4646188 with the risks of atrial fibrillation and cardioembolic stroke in Uygur patients with type 2 diabetes

ACE2 SNPs Total Non-T2D subgroup T2D subgroup
Non-AF (N/%) AF (N/%) RR (95%CI)* P value* Non-AF (N/%) AF (N/%) RR (95%CI)# P value # Non-AF (N/%) AF (N/%) RR (95%CI)# P value #
rs1978124             
CC 277 (60.3) 54 (61.4) 1.00   158 (65.8) 16 (50.0) 1.00   119 (54.3) 38 (67.9) 1.00  
TT + CT 182 (39.7) 34 (38.6) 0.76 (0.42–1.38) 0.364 82 (34.2) 16 (50.0) 1.34 (0.43–4.12) 0.616 100 (45.7) 18 (32.1) 0.66 (0.27–1.63) 0.369
rs2048683             
GG 329 (71.7) 64 (72.7) 1.00   196 (81.7) 26 (81.2) 1.00   133 (60.7) 38 (67.9) 1.00  
TT + GT 130 (28.3) 24 (27.3) 0.66 (0.34–1.26) 0.207 44 (18.3) 6 (18.8) 0.30 (0.06–1.56) 0.151 86 (39.3) 18 (32.1) 1.07 (0.39–2.97) 0.896
rs2074192             
CC 190 (41.4) 50 (56.8) 2.55 (1.35–4.80) 0.004 94 (39.2) 10 (31.3) 0.44 (0.13–1.51) 0.191 96 (48.3) 40 (71.4) 3.22 (1.26–8.24) 0.015
TT + CT 269 (58.6) 38 (43.2) 1.00   146 (60.8) 22 (60.7) 1.00   123 (56.2) 16 (28.6) 1.00  
rs233575             
CC + CT 142 (30.9) 28 (31.8) 0.99 (0.53–1.86) 0.983 48 (20.0) 10 (31.3) 1.59 (0.54–4.68) 0.397 94 (42.9) 18 (32.1) 0.70 (0.18–2.66) 0.598
TT 317 (69.1) 60 (68.2) 1.00   192 (80.0) 22 (60.7) 1.00   125 (57.1) 38 (67.9) 1.00  
rs4240157             
CC + CT 140 (30.5) 48 (54.5) 2.26 (1.27–4.04) 0.006 54 (22.5) 10 (31.3) 0.97 (0.31–3.06) 0.960 86 (39.3) 38 (67.9) 3.38 (1.15–9.98) 0.027
TT 319 (69.5) 40 (45.5) 1.00   186 (77.5) 22 (60.7) 1.00   133 (60.7) 18 (32.1) 1.00  
rs4646156             
AA + AT 134 (29.2) 24 (27.3) 0.61 (0.32–1.16) 0.134 48 (20.0) 6 (18.8) 0.29 (0.06–1.47) 0.134 86 (39.3) 18 (32.1) 0.79 (0.28–2.24) 0.659
TT 325 (70.8) 64 (72.7) 1.00   192 (80.0) 26 (81.2) 1.00   133 (60.7) 38 (67.9) 1.00  
rs4646188             
CC + CT 152 (33.1) 14 (15.9) 1.00   88 (36.7) 8 (25.0) 1.00   64 (29.2) 6 (10.7) 1.00  
TT 307 (66.9) 74 (84.1) 2.37 (1.16–4.86) 0.018 152 (63.3) 24 (75.0) 1.17 (0.28–4.92) 0.827 155 (70.8) 50 (89.3) 3.03 (1.06–8.66) 0.039
rs879922             
CC + CG 244 (53.2) 60 (68.2) 0.95 (0.52–1.75) 0.878 114 (47.5) 14 (43.8) 0.92 (0.35–2.37) 0.857 130 (59.4) 46 (82.1) 1.03 (0.35–3.00) 0.957
GG 215 (46.8) 28 (31.8) 1.00   126 (52.5) 18 (56.3) 1.00   89 (40.6) 10 (17.9) 1.00  
  1. * Model 1: after adjustment for age, HT, T2D, LDL-C and LAD
  2. # Model 2: It is the same as Model 1 with exception of T2D