Distributive characteristics of the CYP2C9 and AGTR1 genetic polymorphisms in Han Chinese hypertensive patients: a retrospective study

Table 4 The distribution of combined genotypes of CYP2C9 and AGTR1 in Han Chinese hypertensive patients

CYP2C9 genotype	AGTR1 genotype	Reactions for β-receptors blockers		Expected efficacy	Expected adverse reactions	Frequencies
CYP2C9 genotype	AGTR1 genotype	Metabolizing capacity	Sensitivity	Expected efficacy	Expected adverse reactions	Frequencies
1/1	AA	EM	Normal	+		84.66% (2048)
1/1	AC	EM	Slightly increased	++		8.43% (204)
1/1	CC	EM	Significantly increased	++		0.21% (5)
1/3	AA	IM	Normal	++		5.46% (132)
1/3	AC	IM	Slightly increased	+++		0.87% (21)
1/3	CC	IM	Significantly increased	+++	+	0.08% (2)
3/3	AA	PM	Normal	+++		0.29% (7)
3/3	AC	PM	Slightly increased	+++	+	0
3/3	CC	PM	Significantly increased	+++	++	0

ISSN: 1471-2261