Table 4 HPA haplotypes of HPA 1–3 in patients and controls

Haplotypesa Frequencies Association test
HPA1 HPA2 HPA3 Hap.freq
Hap.freq Controls (freq) χ2 P valueb Pcc OR (95% CI)*
a a a 193 (0.482) 87 (0.437) 0.947 0.330597 0.910024 1.186 (0.84–1.67)
a a b 125 (0.313) 73 (0.363) 1.672 0.196024 0.729941 0.789 (0.55–1.13)
a b a 23 (0.058) 12 (0.059) 0.007 0.931565 1 0.969 (0.47–1.99)
a b b 22 (0.054) 6 (0.031) 1.639 0.200514 0.738865 1.804 (0.72–4.50)
b a a 17 (0.042) 15 (0.073) 2.743 0.097746 0.460523 0.547 (0.26–1.12)
b a b 15 (0.037) 3 (0.016) 2.023 0.155039 0.636068 2.357 (0.69–7.95)
b b a 2 (0.006) 4 (0.020)
b b b 3 (0.008) 0 (0.000)
1. CAD coronary artery disease
2. *95% confidence interval for difference between Hap.freq case–control; If a CI does not contain 0, frequencies of haplotypes in case and control groups are significantly different at α = 0.05
3. aHPA haplotype (HPA1/HPA2/HPA3) frequency determined by the maximum likelihood method
4. bFisher’s exact test
5. cPc = corrected P, according to the Bonferroni method [Pc = 1 − (1 – P)n], where n = number of comparisons