Table 3 Incident rate ratios, with 95% confidence intervals (CIs) for cardiovascular events following pandemic influenza vaccination (pandemrix) among lower risk individuals
AMI (n = 495) | Stroke (n = 308) | Pulmonary embolism (n = 136) | |||||||
|---|---|---|---|---|---|---|---|---|---|
No. of events | Person-days at risk | IRR (95% CI)b | No. of events | Person-days at risk | IRR (95% CI)b | No. of events | Person-days at risk | IRR (95% CI)b | |
Baseline perioda | 209 | 160,056 | 1.00 (ref.) | 160 | 99,468 | 1.00 (ref.) | 59 | 44,064 | 1.00 (ref) |
Pre-vaccination interval | |||||||||
1–14 days | 2 | 6916 | 0.29 (0.07–1.19) | 4 | 4298 | 0.63 (0.23–1.74) | 1 | 1904 | 0.59 (0.08–4.50) |
On the day of vaccination | – | – | No estimates | – | – | No estimates | – | – | No estimates |
Post-vaccination interval | |||||||||
1–14 days | 29 | 6916 | 4.19 (2.69–6.52) | 11 | 4298 | 1.73 (0.90–3.31) | 4 | 1904 | 2.35 (0.78–7.06) |
15–28 days | 24 | 6916 | 3.17 (1.99–5.07) | 10 | 4298 | 1.51 (0.77–2.97) | 5 | 1904 | 2.61 (0.96–7.08) |
29–59 days | 43 | 15,314 | 2.28 (1.50–3.49) | 22 | 9517 | 1.40 (0.81–2.42) | 7 | 4216 | 1.40 (0.56–3.52) |
60–90 days | 57 | 15,314 | 2.78 (1.79–4.32) | 31 | 9517 | 1.86 (1.04–3.32) | 20 | 4216 | 3.43 (1.57–7.47) |
91–120 days | 46 | 14,820 | 2.27 (1.50–3.44) | 22 | 9210 | 1.37 (0.76–2.46) | 18 | 4080 | 3.10 (1.50–6.41) |
121–180 days | 85 | 29,640 | 1.99 (1.54–2.59) | 48 | 18,420 | 1.54 (1.10–2.17) | 22 | 8160 | 1.80 (1.08–3.00) |