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Table 3 Genetic risk evaluation of 4 SNPs within IL-35 gene and CHD risk

From: Analysis for interaction between interleukin-35 genes polymorphisms and risk factors on susceptibility to coronary heart disease in the Chinese Han population

SNP Genotypes or Alleles Frequencies N (%) Adjusted OR (95% CI)a p-values
CHD cases (N = 921) Controls (N = 926)
EBI3-rs428253
  GG genotype 458 (49.7) 594 (64.1) 1.00 (ref)  
  GC genotype 369 (40.1) 285 (30.8) 1.87 (1.21–2.58)  < 0.001
  CC genotype 94 (10.2) 47 (5.1) 2.06 (1.45–2.75)  < 0.001
  G allele 1285 (69.8) 1473 (79.5) 1.00  
  C allele 557 (30.2) 379 (20.5) 1.91 (1.28–2.64)  < 0.001
P values for HWE   0.097   
EBI3-rs4740
  GG genotype 483 (52.4) 543 (58.6) 1.00 (ref)  
  GA genotype 359 (39.0) 323 (34.9) 1.41 (0.95–1.97) 0.325
  AA genotype 79 (8.6) 60 (6.5) 1.56 (0.87–2.26) 0.561
  G allele 1325 (71.9) 1409 (76.1) 1.00  
  A allele 517 (28.1) 443 (23.9) 1.46 (0.92–2.04) 0.487
P values for HWE   0.205   
IL-12A-rs2243115
  TT genotype 513 (55.7) 633 (68.4) 1.00 (ref)  
  TG genotype 332 (36.1) 257 (27.8) 1.76 (1.32–2.18)  < 0.001
  GG genotype 76 (8.3) 36 (3.9) 1.93 (1.23–2.65)  < 0.001
  T allele 1358 (73.7) 1523 (82.2) 1.00  
  G allele 484 (26.3) 329 (17.8) 1.80 (1.30–2.23)  < 0.001
P values for HWE   0.127   
IL-12A-rs568408
  GG genotype 563 (61.1) 641 (69.2) 1.00 (ref)  
  GA genotype 312 (33.9) 253 (27.3) 1.31 (0.82–1.82) 0.436
  AA genotype 46 (5.0) 32 (3.5) 1.53 (0.74–2.33) 0.628
  G allele 1438 (78.1) 1535 (82.9) 1.00  
  A allele 404 (21.9) 317 (17.1) 1.37 (0.80–1.91) 0.541
P values for HWE   0.259   
  1. aAdjusted for gender, age, status of smoking and alcohol consumption and BMI