Table 3 Genetic risk evaluation of 4 SNPs within IL-35 gene and CHD risk
SNP | Genotypes or Alleles | Frequencies N (%) | Adjusted OR (95% CI)a | p-values | |
|---|---|---|---|---|---|
CHD cases (N = 921) | Controls (N = 926) | ||||
EBI3-rs428253 | |||||
GG genotype | 458 (49.7) | 594 (64.1) | 1.00 (ref) | ||
GC genotype | 369 (40.1) | 285 (30.8) | 1.87 (1.21–2.58) | < 0.001 | |
CC genotype | 94 (10.2) | 47 (5.1) | 2.06 (1.45–2.75) | < 0.001 | |
G allele | 1285 (69.8) | 1473 (79.5) | 1.00 | ||
C allele | 557 (30.2) | 379 (20.5) | 1.91 (1.28–2.64) | < 0.001 | |
P values for HWE | 0.097 | ||||
EBI3-rs4740 | |||||
GG genotype | 483 (52.4) | 543 (58.6) | 1.00 (ref) | ||
GA genotype | 359 (39.0) | 323 (34.9) | 1.41 (0.95–1.97) | 0.325 | |
AA genotype | 79 (8.6) | 60 (6.5) | 1.56 (0.87–2.26) | 0.561 | |
G allele | 1325 (71.9) | 1409 (76.1) | 1.00 | ||
A allele | 517 (28.1) | 443 (23.9) | 1.46 (0.92–2.04) | 0.487 | |
P values for HWE | 0.205 | ||||
IL-12A-rs2243115 | |||||
TT genotype | 513 (55.7) | 633 (68.4) | 1.00 (ref) | ||
TG genotype | 332 (36.1) | 257 (27.8) | 1.76 (1.32–2.18) | < 0.001 | |
GG genotype | 76 (8.3) | 36 (3.9) | 1.93 (1.23–2.65) | < 0.001 | |
T allele | 1358 (73.7) | 1523 (82.2) | 1.00 | ||
G allele | 484 (26.3) | 329 (17.8) | 1.80 (1.30–2.23) | < 0.001 | |
P values for HWE | 0.127 | ||||
IL-12A-rs568408 | |||||
GG genotype | 563 (61.1) | 641 (69.2) | 1.00 (ref) | ||
GA genotype | 312 (33.9) | 253 (27.3) | 1.31 (0.82–1.82) | 0.436 | |
AA genotype | 46 (5.0) | 32 (3.5) | 1.53 (0.74–2.33) | 0.628 | |
G allele | 1438 (78.1) | 1535 (82.9) | 1.00 | ||
A allele | 404 (21.9) | 317 (17.1) | 1.37 (0.80–1.91) | 0.541 | |
P values for HWE | 0.259 | ||||