Table 1 General characteristics of patients with MYBPC3 and MYH7 gene mutation

Age (years)

51.1 ± 14.2

49.8 ± 14.3

55.1 ± 13.3

0.211

Females, n (%)

15 (23.8%)

10 (20.8%)

5 (33.3%)

0.321

BMI (kg/m²)

26.4 ± 4.4

26.1 ± 4.6

27.8 ± 3.1

0.260

Fatigue, n (%)

9 (14.3%)

7 (14.6%)

2 (13.3%)

0.881

Dyspnea, n (%)

25 (39.7%)

21 (43.7%)

4 (26.7%)

0.238

Chest pain, n (%)

6 (9.5%)

4 (8.3%)

2 (13.3%)

0.565

Palpitations, n (%)

13 (20.6%)

8 (16.7%)

5 (33.3%)

0.177

Syncope, n (%)

10 (15.9%)

9 (18.7%)

1 (6.6%)

0.264

Family history of HCM, n (%)

23 (36.5%)

22 (45.8%)

1 (6.6%)

0.014*

Comorbidities

 Diabetes mellitus, n (%)

3 (4.8%)

3 (6.2%)

–

–

 Chronic obstructive pulmonary disease, n (%)

2 (3.2%)

2 (4.2%)

–

–

 Thyroid dysfunction, n (%)

8 (12.7%)

7 (14.6%)

1 (6.7%)

0.422

 Anemia, n (%)

1 (1.6%)

1 (2.1%)

–

–

Laboratory analyses

 Glucose (mmol/l)

5.6 ± 1.2

5.8 ± 1.3

5.0 ± 0.6

0.071

 Creatinine (µmol/l)

84.4 ± 17.7

85.5 ± 18.3

81.3 ± 16.4

0.487

 Blood urea nitrogen (mmol/l)

9.0 ± 12.7

10.2 ± 15.6

6.9 ± 3.9

0.472

 ALT (U/l)

30.1 ± 15.7

31.8 ± 17.0

25.0 ± 10.4

0.268

 Total protein (g/l)

69.1 ± 8.4

69.3 ± 7.2

68.6 ± 11.1

0.853

 Albumin (g/l)

44.0 ± 6.8

44.1 ± 6.4

43.9 ± 8.0

0.948

 Sodium (mmol/l)

140.3 ± 2.1

140.4 ± 2.1

140.2 ± 2.3

0.868

 Potassium (mmol/l)

4.5 ± 0.4

4.5 ± 0.3

4.6 ± 0.5

0.531

 Calcium (mmol/l)

2.3 ± 0.1

2.3 ± 0.1

2.3 ± 0.2

0.689

 NT-proBNP (ng/l)

1328.3 ± 1420.2

1304.5 ± 1457.5

1757.2 ± 1335.2

0.766