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Table 3 Other cardiovascular risk factors in the univariate analysis

From: Predictors of acute cardiovascular events following acute exacerbation period for patients with COPD: a nested case–control study

Category

Variables

Acute CVEs group (n = 30)

No CVEs group (n = 466)

P value

Odd ratio

95% CI

Symptoms and signs

Palpitation

2/20 (10.0%)

9/388 (2.3%)

0.039

4.68

0.94–23.27

20% increase in HR

5/20 (25.0%)

11/386 (2.8%)

 < 0.001

11.36

3.50–36.86

Both lower limb edema

10/20 (50.0%)

70/389 (18.0%)

 < 0.001

4.56

1.83–11.37

Disturbance of consciousness

4/20 (20.0%)

19/387 (4.9%)

0.004

4.84

1.48–15.90

Laboratory tests

Neutrophil (%)

80.85 (73.18–86.05)

75.50 (67.55–83.50)

0.035

  
 

 ≥ 80

16/30 (53.3%)

165/466 (35.4%)

0.048

2.09

0.99–4.38

 

CRP (mg/L) (n = 478)

33.4 (12.45–68.55)

19.2 (4.95–61.1)

NS

  
 

 ≥ 10

24/29 (82.8%)

280/449 (62.4%)

0.028

2.90

1.09–7.74

 

Urea nitrogen (mmol/L)

6.80 (4.55–9.88)

5.50 (4.30–7.10)

0.031

  
 

 ≥ 7.5

14/30 (46.7%)

102/459 (22.2%)

0.002

3.06

1.45–6.49

 

cTnT (ng/mL) (n = 333)

0.02 (0.01–0.03)

0.01 (0–0.02)

0.054

  
 

 > 0.03

6/28 (21.4%)

39/304 (12.8%)

NS

  
 

LDH (U/L)

316 (198–404)

208 (181–257)

0.002

  
 

 > 245

16/25 (64.0%)

120/413 (29.1%)

 < 0.001

4.34

1.87–10.10

 

NT-proBNP

(pg/ml) (n = 218)

993 (268–1875)

296 (139–1070)

0.021

  
 

 ≥ 300

13/17 (76.5%)

100/201 (49.8%)

0.043

  
 

D-dimer (ug/L)

0.77 (0.43–1.21)

0.52 (0.27–1.04)

NS

  
 

 ≥ 0.5

16/25 (64.0%)

235/448 (52.5%)

NS

  
 

FBG (mmol/L)

7.0 (5.6–7.3)

5.5 (4.7–6.8)

0.007

  
 

 ≥ 7

9/27 (33.3%)

95/421 (22.6%)

NS

  
 

Cholesterol (mmol/L)

3.90 (2.92–4.34)

4.19 (3.61–4.98)

0.016

  
 

LDL (mmol/L)

2.20 (1.58–2.67)

2.62 (2.11–3.11)

0.013

  
 

PaO2 (mmHg)

80.50 (64.25–108.25)

78.5 (65–100)

NS

  
 

 ≤ 60

4/28 (14.3%)

80/422 (19.0%)

  
 

PaCO2 (mmHg)

51.0 (39.0–66.0)

47 (41–58)

NS

  
 

 ≥ 50

15/27 (55.6%)

185/416 (44.5%)

  

CT manifestation

Pleural effusion

9/25 (36.6%)

75/389 (19.3%)

0.046

2.34

1.00–5.50

multiple lobes' lesion

6/23 (26.1%)

94/390 (24.1%)

NS

  

Complications

Pneumothorax

4/30 (13.3%)

1/466 (0.2%)

 < 0.001

71.54

7.71–663.4

Pulmonary embolism

2/30 (6.7%)

3/457 (0.6%)

0.03

10.81

1.73–67.38

Electrolyte disturbance

11/30 (36.7%)

53/462 (11.5%)

 < 0.001

4.47

2.02–9.90

  1. Data were shown as n/N (percentage) or median (IQR). P-values between two group were calculated by Fisher’s exact test, Chi-square test, or Mann–Whitney U test
  2. CVEs cardiovascular events, CI confidence index, HR heart rate, CRP C-reactive protein, ESR erythrocyte sedimentation rate, cTnT cardiac muscle isoform of troponin T, LDH lactate dehydrogenase, NT-pro BNP N-terminal pro-brain natriuretic peptide, FBG fasting blood glucose, LDL low-density lipoprotein, PaO2 partial pressure of oxide in artery, PaCO2 partial pressure of carbon dioxide in artery, CT computed tomography