| Cumulative smoking exposure | |||
---|---|---|---|---|
Non-smoker (n = 49) | Low exposure (n = 40) | High exposure (n = 95) | p value | |
Left ventricular ejection fraction (%) | 70.4 (64.7– 72.2) | 67.3 (62.6–70.9) | 65.3 (62.5–69.3)* | 0.001 |
Interventricular septum thickness (mm) | 9.2 ± 1.2 | 9.1 ± 1.0 | 9.4 ± 1.2 | 0.31 |
Left ventricular end-diastolic diameter (mm) | 41.0 (37.1–44.2) | 45.1 (41.9–47.7)* | 44.5 (41.5–47.6)* | 0.002 |
Left ventricular end-systolic diameter (mm) | 24.6 (22.3–25.8) | 26.7 (25.1–30.0)* | 28.1 (25.6–30.4)* | < 0.001 |
Posterior left ventricular wall thickness (mm) | 9.3 (8.5–10.1) | 9.5 (8.8–10.0) | 9.7 (8.8–10.2) | 0.31 |
Left atrial diameter (mm) | 33.8 ± 4.9 | 34.4 ± 4.8 | 34.0 ± 5.4 | 0.84 |
Left atrial volume index (ml/m2) | 32.0 (25.5– 39.6) | 28.7 (24.1–35.4) | 27.8 (24.7–33.3) | 0.076 |
Left ventricular end-diastolic volume index (ml/m2) | 39.4 (34.0–50.7) | 48.6 (41.1–55.7)* | 46.1 (38.7–53.9)* | 0.013 |
Left ventricular end-systolic volume index (ml/m2) | 12.2 (10.1–14.8) | 14.9 (13.3–19.3)* | 16.1 (13.1–18.9)* | < 0.001 |
Left ventricular mass index (g/m2) | 80.0 (67.7–92.3) | 82.9 (70.6–90.7) | 82.9 (71.7–94.9) | 0.51 |
E wave velocity (cm/s) | 62.3 ± 16.0 | 61.8 ± 11.9 | 61.0 ± 15.7 | 0.87 |
E wave deceleration time (ms) | 204 (180–232) | 192 (168–243) | 197 (162–259) | 0.80 |
A wave velocity (cm/s) | 85.5 (71.0–100) | 73.4 (61.9–84.1)* | 75.8 (61.5–88.7)* | 0.003 |
E/A | 0.70 (0.60–0.80) | 0.85 (0.70–1.00)* | 0.80 (0.60–1.00)* | 0.020 |
e′ velocity (cm/s) | 7.2 (6.0–8.3) | 8.4 (6.6–10.6)* | 8.0 (6.7–9.8) | 0.004 |
a′ velocity (cm/s) | 9.4 (8.0–11.0) | 9.9 (8.1–11.4) | 9.4 (8.2–11.5) | 0.99 |
E/e′ (lateral) | 7.6 (6.2–11.0) | 7.6 (6.6–8.9) | 7.6 (5.8–8.9) | 0.29 |
Left ventricular global longitudinal strain (%) | − 20.6 ± 1.6 | − 20.3 ± 1.3 | − 20.2 ± 1.8 | 0.37 |
Right atrial area index (cm/m2) | 8.8 (7.6–10.3) | 8.2 (7.4–9.1) | 8.4 (7.1–10.3) | 0.58 |
Right ventricular end-diastolic area index (cm2/m2) | 8.0 (7.1–9.6) | 8.8 (7.2–9.8) | 8.9 (7.6–10.4) | 0.078 |
Right ventricular end-systolic area index (cm2/m2) | 4.0 (3.7–4.9) | 4.8 (4.0–6.0)* | 4.9 (4.1–5.9)* | 0.001 |
Right ventricular fractional area change (%) | 48.4 (42.4–54.5) | 46.0 (40.7–50.5) | 45.7 (40.9–49.2) | 0.063 |
Tricuspid valve annular diameter (cm) | 26.8 ± 4.7 | 28.4 ± 4.5 | 30.0 ± 4.4* |  < 0.001 |
Tricuspid annular plane systolic excursion (mm) | 20.6 ± 4.5 | 20.6 ± 3.2 | 21.4 ± 3.9 | 0.40 |
s't velocity (cm/s) | 11.2 (10.3–13.3) | 11.5 (10.2–12.9) | 11.9 (10.7–13.3) | 0.72 |
e't velocity (cm/s) | 7.8 (6.3–9.4) | 8.3 (7.3–10.6) | 8.2 (6.9–9.6) | 0.14 |
e't/a't | 0.55 (0.43–0.64) | 0.68 (0.54–0.85)* | 0.63 (0.49–0.76)* | 0.003 |
Right ventricular global longitudinal strain (%) | − 21.2 ± 2.8 | − 20.9 ± 2.1 | − 21.1 ± 2.8 | 0.88 |
Inferior vena cava (mm) | 12.8 (10.9–14.3) | 14.5 (12.5–15.6)* | 13.6 (12.0–15.7) | 0.034 |