Table 3 Comparative analysis of the effectiveness by independent and combined diagnosis of three factors for vulnerable plaques
From: Early identification of carotid vulnerable plaque in asymptomatic patients
Variable | ROC Area | 95%CI | Sensitivity (%) | Specificity (%) | Positive predictive value (%) | Negative predictive value (%) | Diagnostic accuracy (%) | P | Critical value | Positive and negative likelihood ratios | Youden index |
|---|---|---|---|---|---|---|---|---|---|---|---|
MMP-9 | 0.847 | 0.791 ~ 0.903 | 88.36 | 70.75 | 80.63 | 81.52 | 80.95 | 0.000 | 282.74 | 18.36 | 0.591 |
LOX-1 | 0.630 | 0.560 ~ 0.700 | 85.62 | 24.53 | 60.98 | 55.32 | 59.92 | 0.000 | 223.78 | 1.94 | 0.102 |
YKL-40 | 0.646 | 0.576 ~ 0.716 | 81.51 | 25.47 | 60.10 | 50.00 | 57.94 | 0.000 | 215.98 | 1.51 | 0.070 |
MMP-9 + LOX-1 + YKL-40 | 0.850 | 0.795 ~ 0.905 | 87.67 | 81.13 | 86.49 | 82.69 | 84.92 | 0.000 | – | 30.57 | 0.688 |
10-year ICVD | 0.590 | 0.520 ~ 0.661 | 85.62 | 16.98 | 58.69 | 46.15 | 56.75 | 0.014 | – | 1.22 | 0.026 |
Carotid plaque core | 0.654 | 0.586 ~ 0.721 | 75.34 | 43.4 | 64.71 | 56.10 | 61.90 | 0.000 | – | 2.34 | 0.187 |