Variables | Neprilysin ≤76.0 pg/ml (n = 348) | Neprilysin > 76.0 pg/ml (n = 346) | P value |
---|---|---|---|
Age (years) | 66.8 ± 11.2 | 64.9 ± 12.4 | 0.027 |
Male | 231 (66.4%) | 234 (67.6%) | 0.394 |
Body mass index (Kg/m2) | 24.5 ± 4.1 | 24.5 ± 4.1 | 0.983 |
Hypertension | 238 (68.4%) | 249 (72.0%) | 0.172 |
Diabetes mellitus | 138 (39.7%) | 124 (35.8%) | 0.169 |
Dyslipidemia | 123 (35.9%) | 120 (35.4%) | 0.482 |
Smoking | 90 (25.9%) | 110 (31.8%) | 0.050 |
Family history of coronary artery disease | 20 (5.7%) | 33 (9.5%) | 0.041 |
Chronic kidney disease | 16 (4.6%) | 17 (4.9%) | 0.493 |
Prior stroke | 37 (10.6%) | 37 (10.7%) | 0.538 |
Prior myocardial infarction | 32 (9.2%) | 23 (6.6%) | 0.135 |
Prior percutaneous coronary intervention | 46 (13.2%) | 43 (12.4%) | 0.422 |
Clinical presentation | Â | Â | 0.982 |
 Stable angina | 19 (5.5%) | 22 (6.4%) |  |
 Unstable angina | 153 (44.0%) | 155 (44.8%) |  |
 NSTEMI | 110 (31.6%) | 107 (30.9%) |  |
 STEMI | 60 (17.2%) | 56 (16.2%) |  |
 Silent myocardial ischemia | 6 (1.7%) | 6 (1.7%) |  |
Left ventricular ejection fraction (%) | 54.5 ± 12.1 | 55.6 ± 11.3 | 0.222 |
Total cholesterol (mg/dl) | 165.6 ± 46.3 | 164.2 ± 43.2 | 0.676 |
Triglyceride (mg/dl) | 141.0 ± 86.0 | 154.1 ± 133.4 | 0.137 |
HDL cholesterol (mg/dl) | 41.6 ± 10.5 | 41.3 ± 9.9 | 0.682 |
LDL cholesterol (mg/dl) | 101.0 ± 34.1 | 99.0 ± 31.8 | 0.415 |
High-sensitivity C-reactive protein (mg/l) | 8.4 ± 23.9 | 10.0 ± 28.0 | 0.406 |
eGFR (ml/min/1.73m2) | 69.6 ± 26.4 | 73.8 ± 30.8 | 0.056 |
NT-proBNP (pg/ml) | 1384.0 ± 4585.9 | 1919.1 ± 6243.0 | 0.199 |
Culprit lesion | Â | Â | 0.628 |
 Left anterior descending | 171 (51.5%) | 165 (49.8%) |  |
 Left circumflex | 62 (18.7%) | 54 (16.3%) |  |
 Right coronary artery | 83 (25.0%) | 95 (28.7%) |  |
 Left main | 15 (4.5%) | 17 (5.1%) |  |
Extent of coronary artery disease | Â | Â | 0.256 |
 1-vessel disease | 164 (49.4%) | 146 (44.1%) |  |
 2-vessel disease | 100 (30.1%) | 119 (36.0%) |  |
 3-vessel disease | 68 (20.5%) | 66 (19.9%) |  |
Multivessel disease | 103 (29.6%) | 112 (32.4%) | 0.240 |
Number of total stents | 1.6 ± 1.0 | 1.7 ± 1.2 | 0.139 |
Mean diameter of stents | 3.10 ± 0.43 | 3.11 ± 0.41 | 0.677 |
Total length of stents | 42.2 ± 28.8 | 46.8 ± 35.4 | 0.065 |