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Table 1 Baseline clinical and angiographic characteristics

From: Soluble neprilysin and long-term clinical outcomes in patients with coronary artery disease undergoing percutaneous coronary intervention: a retrospective cohort study

Variables

Neprilysin

≤76.0 pg/ml

(n = 348)

Neprilysin

> 76.0 pg/ml

(n = 346)

P value

Age (years)

66.8 ± 11.2

64.9 ± 12.4

0.027

Male

231 (66.4%)

234 (67.6%)

0.394

Body mass index (Kg/m2)

24.5 ± 4.1

24.5 ± 4.1

0.983

Hypertension

238 (68.4%)

249 (72.0%)

0.172

Diabetes mellitus

138 (39.7%)

124 (35.8%)

0.169

Dyslipidemia

123 (35.9%)

120 (35.4%)

0.482

Smoking

90 (25.9%)

110 (31.8%)

0.050

Family history of coronary artery disease

20 (5.7%)

33 (9.5%)

0.041

Chronic kidney disease

16 (4.6%)

17 (4.9%)

0.493

Prior stroke

37 (10.6%)

37 (10.7%)

0.538

Prior myocardial infarction

32 (9.2%)

23 (6.6%)

0.135

Prior percutaneous coronary intervention

46 (13.2%)

43 (12.4%)

0.422

Clinical presentation

  

0.982

 Stable angina

19 (5.5%)

22 (6.4%)

 

 Unstable angina

153 (44.0%)

155 (44.8%)

 

 NSTEMI

110 (31.6%)

107 (30.9%)

 

 STEMI

60 (17.2%)

56 (16.2%)

 

 Silent myocardial ischemia

6 (1.7%)

6 (1.7%)

 

Left ventricular ejection fraction (%)

54.5 ± 12.1

55.6 ± 11.3

0.222

Total cholesterol (mg/dl)

165.6 ± 46.3

164.2 ± 43.2

0.676

Triglyceride (mg/dl)

141.0 ± 86.0

154.1 ± 133.4

0.137

HDL cholesterol (mg/dl)

41.6 ± 10.5

41.3 ± 9.9

0.682

LDL cholesterol (mg/dl)

101.0 ± 34.1

99.0 ± 31.8

0.415

High-sensitivity C-reactive protein (mg/l)

8.4 ± 23.9

10.0 ± 28.0

0.406

eGFR (ml/min/1.73m2)

69.6 ± 26.4

73.8 ± 30.8

0.056

NT-proBNP (pg/ml)

1384.0 ± 4585.9

1919.1 ± 6243.0

0.199

Culprit lesion

  

0.628

 Left anterior descending

171 (51.5%)

165 (49.8%)

 

 Left circumflex

62 (18.7%)

54 (16.3%)

 

 Right coronary artery

83 (25.0%)

95 (28.7%)

 

 Left main

15 (4.5%)

17 (5.1%)

 

Extent of coronary artery disease

  

0.256

 1-vessel disease

164 (49.4%)

146 (44.1%)

 

 2-vessel disease

100 (30.1%)

119 (36.0%)

 

 3-vessel disease

68 (20.5%)

66 (19.9%)

 

Multivessel disease

103 (29.6%)

112 (32.4%)

0.240

Number of total stents

1.6 ± 1.0

1.7 ± 1.2

0.139

Mean diameter of stents

3.10 ± 0.43

3.11 ± 0.41

0.677

Total length of stents

42.2 ± 28.8

46.8 ± 35.4

0.065

  1. eGFR indicates estimated glomerular filtration rate, HDL high-density lipoprotein, LDL low-density lipoprotein, NSTEMI non-ST-segment elevation myocardial infarction, NT-proBNP N-terminal pro-B-type natriuretic peptide, STEMI ST-segment elevation myocardial infarction