Table 2 Baseline Characteristics and Interventions of Included Trials
Author | Group | Patients | Age | Sex | Time of administration | Milrinone dose | Length of infusion | Duration of follow-up | |
|---|---|---|---|---|---|---|---|---|---|
| Â | (n) | (y) | (M/F) | Bolus | Infusion | ||||
Arbeus M [38] | MIL | 22 | 63 ± 10 | 20/2 | After release of aortic clamp | 50 μg/kg | None | Bolus only | Hospital Stay |
Ctrl | 22 | 62 ± 9 | 17/5 | ||||||
Couture P [39] | MIL | 25 | 67 ± 8 | 19/6 | After anesthesia induction | 50 μg/kg | 0.5 μg/kg/min | Until skin closure | Hospital Stay |
Ctrl | 25 | 70 ± 7 | 19/6 | ||||||
Doolan LA [40] | MIL | 15 | 65 ± 10.4 | 14/1 | 15 min before weaning from CPB | 50 μg/kg | 0.5 μg/kg/min | 4 h or longer | 30 day |
Ctrl | 15 | 67 ± 8.6 | 14/1 | ||||||
Guo YJ [9] | MIL | 31 | 56 ± 6 | 21/10 | After release of aortic clamp | 50 μg/kg | 0.5 μg/kg/min | 24 h | Hospital Stay |
Ctrl | 31 | 54 ± 6 | 20/11 | ||||||
Hadadzadeh M [41] | MIL | 40 | 62 ± 10.7 | 31/9 | After anesthesia induction | 50 μg/kg | 0.5 μg/kg/min | 24 h | ICU Stay |
Ctrl | 40 | 63 ± 9.6 | 26/14 | ||||||
Hamada Y [42] | MIL | 10 | 66.2 ± 8.1 | 6/4 | After release of aortic clamp | 50 μg/kg | None | Bolus only | Operating Room |
Ctrl | 10 | 62.4 ± 6.5 | 6/4 | ||||||
Hayashida N [43] | MIL | 12 | 63.3 ± 2.8 | 7/5 | After anesthesia induction | None | 0.5 μg/kg/min | 24 h | 72 h |
Ctrl | 12 | 62.7 ± 2.8 | 9/3 | ||||||
Jebeli M [44] | MIL | 35 | 56.9 ± 9.7 | 25/10 | After release of aortic clamp | 50 μg/kg | 0.5 μg/kg/min | 24 h | Hospital Stay |
Ctrl | 35 | 58.2 ± 8.4 | 28/7 | ||||||
Jo HR [45] | MIL | 20 | 67.0 ± 9.2 | 12/8 | After sternotomy | None | 0.5 μg/kg/min | Until skin closure | Hospital Stay |
Ctrl | 20 | 64.1 ± 9.9 | 11/9 | ||||||
Kwak YL [46] | MIL | 29 | 61.5 ± 8.2 | 21/8 | After IMA harvest | None | 0.5 μg/kg/min | End of anastomosis | Hospital Stay |
Ctrl | 33 | 60.4 ± 8.4 | 26/7 | ||||||
Lee JH [32] | MIL | 24 | 63 ± 8 | 20/4 | After sternotomy | None | 0.5 μg/kg/min | Until skin closure | Hospital Stay |
Ctrl | 26 | 62 ± 8 | 20/6 | ||||||
Möllhoff T [47] | MIL | 11 | 60 ± 8 | Not specified | After anesthesia induction | 30 μg/kg | 0.5 μg/kg/min | Unspecified | 1 Year |
Ctrl | 11 | 61 ± 6 | |||||||
Shi Y [53] | MIL | 25 | Not specified | Not specified | After anesthesia induction | 50 μg/kg | 0.5 μg/kg/min | Until skin closure | 6 month |
Ctrl | 24 | High: 75 μg/kg | High: 0.75 μg/kg/min | ||||||
Song JW [54] | MIL | 31 | 67.2 ± 7.6 | 14/17 | After harvesting the left | None | 0.5 μg/kg/min | 31 ± 7 min | Hospital Stay |
Ctrl | 31 | 65.7 ± 7.9 | 21/10 | internal mammary artery | |||||
Yamaguchi A [55] | MIL | 14 | 64.1 ± 8 | 13/1 | After induction of CPB | None | 0.5 μg/kg/min | 48 h | ICU Stay |
Ctrl | 14 | 65.2 ± 8.5 | 13/1 | ||||||
Yamaura K [56] | MIL | 10 | 66 ± 6 | 7/3 | After induction of CPB | None | 0.25 μg/kg/min | 1 h after in ICU | Hospital Stay |
Ctrl | 10 | 57 ± 16 | 6/4 | ||||||