Table 2 Biological and echocardiographic data according to neprilysin levels. ***p < 0.001 vs. baseline
Overall (n = 68) | Neprilysin level ≤ 125 pg/mL (n = 38) | Neprilysin level 126–450 pg/mL (n = 15) | Neprilysin level > 450 pg/mL (n = 15) | Overall p.value | Highest-level vs. lower groups p.value | |
|---|---|---|---|---|---|---|
At baseline | ||||||
NT-proBNP, pg/mL | 187 [64, 790] | 184 [66, 1155] | 287 [87, 566] | 217 [65, 1103] | 0.77 | 0.47 |
hs-cTnI, pg/mL | 1947 [159, 9948] | 1511 [156, 9794] | 1136 [327, 6711] | 2765 [574, 10,492] | 0.64 | 0.38 |
Neprilysin, pg/mL | 125 [125, 432] | – | 350 [183, 411] | 1070 [781, 1824] | ||
At baseline | ||||||
EDV, mL/m2 | 53.8 ± 13.0 | 55.1 ± 12.4 | 56.0 ± 13.5 | 48.3 ± 13.3 | 0.18 | 0.07 |
ESV, mL/m2 | 28.2 [22.4, 34.7] | 27.8 [23.2, 34.9] | 28.8 [24.3, 32.8] | 28.5 [21.1, 36.0] | 0.97 | 0.82 |
LVEF, % | 45.0 ± 8.5 | 46.4 ± 8.3 | 47.1 ± 8.1 | 39.1 ± 6.9 | < 0.01 | < 0.01 |
At follow-up | ||||||
EDV, mL/m2 | 56.6 ± 15.0 | 57.8 ± 13.6 | 58.7 ± 19.9 | 51.6 ± 12.6 | 0.35 | 0.15 |
%increase in EDV | 4.6 [−8.6, 18.6] | −0.1 [8.9, 17.4] | 5.9 [−11.4, 22.1] | 10.7 [−5.3, 20.5] | 0.69 | 0.39 |
ΔEDV, mL/m2 | 5.4 ± 23.2 | 5.5 ± 22.7 | 5.4 ± 28.6 | 5.1 ± 20.0 | 1 | 0.96 |
ESV, mL/m2 | 25.4 [19.0, 34.8] | 25.8 [19.6, 32.7] | 25.9 [18.9, 36.5] | 25.1 [19.1, 32.3] | 0.91 | 0.66 |
%increase in ESV | −14.3 [−23.3, 10.5] | −10.9 [−22.1, 9.7] | −11.1 [−27.0, 28.8] | −15.2 [−24.2, 1.6] | 0.69 | 0.44 |
ΔESV, mL/m2 | −4.2 ± 17.7 | −3.7 ± 17.3 | −0.8 ± 20.9 | −8.9 ± 15.4 | 0.46 | 0.26 |
LVEF, % | 51.9 ± 9.2*** | 53.0 ± 8.9*** | 50.6 ± 9.7 | 50.4 ± 9.9*** | 0.55 | 0.49 |
%increase in LVEF | 17.7 ± 22.0 | 16.0 ± 19.4 | 9.1 ± 21.5 | 30.3 ± 24.5 | 0.022 | 0.01 |
ΔLVEF, % | 7.0 ± 8.3 | 6.6 ± 7.3 | 3.6 ± 9.0 | 11.3 ± 8.4 | 0.031 | 0.02 |