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Table 2 Biological and echocardiographic data according to neprilysin levels. ***p < 0.001 vs. baseline

From: Serum neprilysin levels are associated with myocardial stunning after ST-elevation myocardial infarction

  Overall (n = 68) Neprilysin level ≤ 125 pg/mL (n = 38) Neprilysin level 126–450 pg/mL (n = 15) Neprilysin level > 450 pg/mL (n = 15) Overall p.value Highest-level vs. lower groups p.value
At baseline
 NT-proBNP, pg/mL 187 [64, 790] 184 [66, 1155] 287 [87, 566] 217 [65, 1103] 0.77 0.47
 hs-cTnI, pg/mL 1947 [159, 9948] 1511 [156, 9794] 1136 [327, 6711] 2765 [574, 10,492] 0.64 0.38
 Neprilysin, pg/mL 125 [125, 432] 350 [183, 411] 1070 [781, 1824]   
At baseline
 EDV, mL/m2 53.8 ± 13.0 55.1 ± 12.4 56.0 ± 13.5 48.3 ± 13.3 0.18 0.07
 ESV, mL/m2 28.2 [22.4, 34.7] 27.8 [23.2, 34.9] 28.8 [24.3, 32.8] 28.5 [21.1, 36.0] 0.97 0.82
 LVEF, % 45.0 ± 8.5 46.4 ± 8.3 47.1 ± 8.1 39.1 ± 6.9 < 0.01 < 0.01
At follow-up
 EDV, mL/m2 56.6 ± 15.0 57.8 ± 13.6 58.7 ± 19.9 51.6 ± 12.6 0.35 0.15
 %increase in EDV 4.6 [−8.6, 18.6] −0.1 [8.9, 17.4] 5.9 [−11.4, 22.1] 10.7 [−5.3, 20.5] 0.69 0.39
 ΔEDV, mL/m2 5.4 ± 23.2 5.5 ± 22.7 5.4 ± 28.6 5.1 ± 20.0 1 0.96
 ESV, mL/m2 25.4 [19.0, 34.8] 25.8 [19.6, 32.7] 25.9 [18.9, 36.5] 25.1 [19.1, 32.3] 0.91 0.66
 %increase in ESV −14.3 [−23.3, 10.5] −10.9 [−22.1, 9.7] −11.1 [−27.0, 28.8] −15.2 [−24.2, 1.6] 0.69 0.44
 ΔESV, mL/m2 −4.2 ± 17.7 −3.7 ± 17.3 −0.8 ± 20.9 −8.9 ± 15.4 0.46 0.26
 LVEF, % 51.9 ± 9.2*** 53.0 ± 8.9*** 50.6 ± 9.7 50.4 ± 9.9*** 0.55 0.49
 %increase in LVEF 17.7 ± 22.0 16.0 ± 19.4 9.1 ± 21.5 30.3 ± 24.5 0.022 0.01
 ΔLVEF, % 7.0 ± 8.3 6.6 ± 7.3 3.6 ± 9.0 11.3 ± 8.4 0.031 0.02
  1. EDV end-diastolic volume, ESV end-systolic volume, hs-cTnI high-sensibility cardiac troponin I, LVEF left ventricular ejection fraction