| |
Overall (n = 68)
|
Neprilysin level ≤ 125 pg/mL (n = 38)
|
Neprilysin level 126–450 pg/mL (n = 15)
|
Neprilysin level > 450 pg/mL (n = 15)
|
Overall p.value
|
Highest-level vs. lower groups p.value
|
|---|
|
At baseline
|
|
NT-proBNP, pg/mL
|
187 [64, 790]
|
184 [66, 1155]
|
287 [87, 566]
|
217 [65, 1103]
|
0.77
|
0.47
|
|
hs-cTnI, pg/mL
|
1947 [159, 9948]
|
1511 [156, 9794]
|
1136 [327, 6711]
|
2765 [574, 10,492]
|
0.64
|
0.38
|
|
Neprilysin, pg/mL
|
125 [125, 432]
|
–
|
350 [183, 411]
|
1070 [781, 1824]
| | |
|
At baseline
|
|
EDV, mL/m2
|
53.8 ± 13.0
|
55.1 ± 12.4
|
56.0 ± 13.5
|
48.3 ± 13.3
|
0.18
|
0.07
|
|
ESV, mL/m2
|
28.2 [22.4, 34.7]
|
27.8 [23.2, 34.9]
|
28.8 [24.3, 32.8]
|
28.5 [21.1, 36.0]
|
0.97
|
0.82
|
|
LVEF, %
|
45.0 ± 8.5
|
46.4 ± 8.3
|
47.1 ± 8.1
|
39.1 ± 6.9
|
< 0.01
|
< 0.01
|
|
At follow-up
|
|
EDV, mL/m2
|
56.6 ± 15.0
|
57.8 ± 13.6
|
58.7 ± 19.9
|
51.6 ± 12.6
|
0.35
|
0.15
|
|
%increase in EDV
|
4.6 [−8.6, 18.6]
|
−0.1 [8.9, 17.4]
|
5.9 [−11.4, 22.1]
|
10.7 [−5.3, 20.5]
|
0.69
|
0.39
|
|
ΔEDV, mL/m2
|
5.4 ± 23.2
|
5.5 ± 22.7
|
5.4 ± 28.6
|
5.1 ± 20.0
|
1
|
0.96
|
|
ESV, mL/m2
|
25.4 [19.0, 34.8]
|
25.8 [19.6, 32.7]
|
25.9 [18.9, 36.5]
|
25.1 [19.1, 32.3]
|
0.91
|
0.66
|
|
%increase in ESV
|
−14.3 [−23.3, 10.5]
|
−10.9 [−22.1, 9.7]
|
−11.1 [−27.0, 28.8]
|
−15.2 [−24.2, 1.6]
|
0.69
|
0.44
|
|
ΔESV, mL/m2
|
−4.2 ± 17.7
|
−3.7 ± 17.3
|
−0.8 ± 20.9
|
−8.9 ± 15.4
|
0.46
|
0.26
|
|
LVEF, %
|
51.9 ± 9.2***
|
53.0 ± 8.9***
|
50.6 ± 9.7
|
50.4 ± 9.9***
|
0.55
|
0.49
|
|
%increase in LVEF
|
17.7 ± 22.0
|
16.0 ± 19.4
|
9.1 ± 21.5
|
30.3 ± 24.5
|
0.022
|
0.01
|
|
ΔLVEF, %
|
7.0 ± 8.3
|
6.6 ± 7.3
|
3.6 ± 9.0
|
11.3 ± 8.4
|
0.031
|
0.02
|
- EDV end-diastolic volume, ESV end-systolic volume, hs-cTnI high-sensibility cardiac troponin I, LVEF left ventricular ejection fraction
