Fig. 3

β1AA inhibited the PGC-1α related factor expression. β1AA significantly inhibited the mRNA expression of PGC-1α (a) and VEGF (b). And the effect of β1AA on mRNA expression of PGC-1α could also be mimicked by isoprenaline. However, isoprenaline promoted the mRNA expression of VEGF (n = 5). cELISA test for secreted VEGF in the supernatant of the medium (n = 5). d Raw data of results of WB test. e Relative expression content of PGC-1α, VEGF and caspase3 (n = 5). β1AA increased the protein expression of caspase3, and inhibited the protein expression of PGC-1α and VEGF. The effects of β1AA could be inhibited by atenolol. And the effect of β1AA on protein expression of PGC-1α could also be mimicked by isoprenaline. However, isoprenaline promoted the protein expression of VEGF expression rather than inhibition as β1AA did. **, P ≤ 0.01. n.s., no statistical significance. Group data presented by mean ± SEM