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Table 6 Characteristics of Patients based on the WHO Functional Class (n = 602)

From: The COngenital HeARt Disease in adult and Pulmonary Hypertension (COHARD-PH) registry: a descriptive study from single-center hospital registry of adult congenital heart disease and pulmonary hypertension in Indonesia

Characteristics

WHO class I (n = 258)

WHO class II (n = 277)

WHO class III-IV (n = 67)

P value

Age at Enrollment (years) [mean ± SD]

34.5 ± 12.9

34.9 ± 12.8

36.6 ± 12.2

0.498

Gender [n (%)]

 Males

55 (21.3)

53 (19.1)

7 (10.4)

0.131

 Females

203 (78.7)

224 (80.9)

60 (89.6)

 

Body Mass Index [mean ± SD]

19.9 ± 3.4

19.2 ± 3.9

20.9 ± 14.7

0.064

Oxygen Saturation (%)[mean ± SD]a

96.9 ± 3.2

95.4 ± 5.2

92.6 ± 8.1

< 0.001

6 Minute Walk Distance (meter)[mean ± SD]b

403.9 ± 80.2

333.1 ± 88.4

276.6 ± 104.6

< 0.001

Hemoglobin (g/dL) [mean ± SD]c

13.8 ± 2.0

13.9 ± 2.1

14.0 ± 2.5

0.569

Hematocrit (%) [mean ± SD]d

41.4 ± 5.3

41.6 ± 6.4

41.9 ± 7.6

0.783

NTproBNP (pg/mL) [median (IQR)]e

178.0 (91.9–718.6)

556.9 (159.6–1687.0)

929.1 (383.0–2882.0)

0.022

Congenital Anomaly [n (%)]

   

0.001

 ASD (n = 523)

207 (80.2)

252 (91.0)

64 (95.5)

 

 VSD (n = 41)

29 (11.2)

9 (3.2)

3 (4.5)

 

 PDA (n = 31)

21 (8.1)

10 (3.6)

0 (0)

 

 Others (n = 7)

1 (0.5)

6 (2.2)

0 (0)

 

Echocardiography parameters

 mPAP (mmHg) [mean ± SD]f

32.6 ± 14.7

37.3 ± 15.2

43.5 ± 15.0

< 0.001

 TVRG (mmHg) [mean ± SD]g

50.7 ± 32.7

66.5 ± 34.1

80.8 ± 35.4

< 0.001

 RA diameter (mm) [mean ± SD]h

44.8 ± 7.5

46.6 ± 8.1

47.4 ± 8.6

0.017

 RV diameter (mm) [mean ± SD]i

39.8 ± 7.7

44.4 ± 8.4

45.4 ± 7.5

< 0.001

 TAPSE (mm) [mean ± SD]j

25.4 ± 5.3

25.2 ± 5.8

22.7 ± 5.4

0.002

 Left ventricle EF (%)[mean ± SD]k

68.9 ± 7.4

69.7 ± 9.1

66.1 ± 11.6

0.011

RHC parameters

mPAP (mmHg) [median (IQR)]l

28.0 (20.3–46.0)

40.0 (26.0–58.0)

52.5 (32.8–68.5)

< 0.001

PVRi (Wood Unit.m2) [median (IQR)]m

2.2 (1.4–5.3)

3.8 (1.5–13.5)

10.2 (2.1–21.6)

< 0.001

Flow Ratio [median (IQR)]n

2.5 (1.7–3.6)

2.4 (1.5–3.4)

1.8 (1.0–3.1)

0.115

  1. a data of 488 patients;b data of 442 patients; c data of 439 patients;d data of 444 patients;e data of 294 patients;f data of 504 patients;g data of 519 patients; h data of 542 patients; i data of 566 patients; j data of 572 patients; k data of 581 patients; l data of 582 patients; m data of 515 patients;n data of 530 patients;
  2. WHO world health organisation, PAH pulmonary artery hypertension, ASD atrial septal defect, VSD ventricular septal defect, PDA patent ductus arteriosus, AP aortopulmonal, AVSD atrioventricular septal defects, mPAP mean pulmonary artery pressure, TVRG tricuspid valve regurgitation gradient, RA right atrium, RV right ventricle, TAPSE tricuspid annular plane systolic excursion, EF ejection fraction, mPAP mean pulmonary artery pressure, PVRi pulmonary vascular resistance index
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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