Fig. 3

Echocardiogram findings for previously reported family members. Legend: II.3 A: Anterior and posterior aortic leaflets (orange arrows) of a bicuspid aortic valve. II.3B: Calcified aortic valve (red arrow) with a dilated ascending aorta. II.3C: Cardiac MR image showing the ascending aortic aneurysm dilated at 5.8 cm. III.3A: Two leaflets of the bicuspid aortic valve (orange arrows). III.3B: Doming of the aortic valve (blue arrow), consistent with a bicuspid aortic valve, and mitral valve prolapse (red arrow). III.4A: Anterior and posterior leaflets (orange arrows) of a bicuspid aortic valve. III.4B: Thickened mitral valve (red arrow). III.5A: Tri-leaflet aortic valve. III.5B: Thickened mitral valve leaflets (red arrow). IV.1A: Bicuspid aortic valve leaflets (orange arrows). IV.1B-C: Septal defect between the left and right atrium