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Table 3 MPXI and biochemical measurements of the study cohorts

From: Neutrophil activation and neutrophil derived neutrophil extracellular trap formation in patients with coronary artery ectasia

 CAECADCONp valueCAE vs CADCAE vs CONCAD vs CON
Number of patients303030    
MPXI1.02 ± 3.013.22 ± 3.033.52 ± 4.250.013*0.016*0.007*0.745
PSGL1, ng/mL581.07 ± 162.45450.76 ± 166.43379.93 ± 114.750.000*0.001*0.000*0.070
E-selectin, ng/mL†6.49(2.65–17.82)4.74(1.91–14.32)3.06(1.45–4.86)0.036*0.4010.011*0.082
L-selectin, ng/mL1186.86 ± 356.621118 ± 631.53801.05 ± 190.330.002*0.5390.001*0.006*
IL1β, pg/mL† (%)46.1 ± 121.09 (73.3)19.72 ± 30.24 (46.7)4.14 ± 14.79 (16.7)0.000 (0.000*)0.296 (0.035)0.000* (0.000*)0.018* (0.012*)
IL8, pg/mL† (%)20.38 ± 88.5 (10)0.54 ± 2.93 (3.3)0 ± 0 (0)0.161 (0.160)   
TNFα, pg/mL† (%)1.58 ± 8.56 (6.7)0.15 ± 0.8 (3.3)0 ± 0 (0)0.360 (0.355)   
IL17, pg/mL† (%)3.21 ± 17.37 (6.7)7.36 ± 26.2 (16.7)0.29 ± 1.59 (3.3)0.169 (0.168)   
dsDNA, ng/mL†284.31(258.33–449.91)225.12(203.34–257.13)247.37(231.04–273.01)0.000*0.000*0.001*0.041*
SLPI, ng/mL52.24 ± 18.4144.47 ± 14.5740.02 ± 6.800.004*0.2070.005*0.352
  1. Pearson’s chi-square test was used for frequency differences between categories. ANOVA or Kruskal-Wallis H test (†) was used for continuous variables, LSD or Dunnett T3 was used for multiple comparisons
  2. CAE Coronary artery ectasia, CAD Coronary artery disease, CON Normal coronary artery group, MPXI Intra-neutrophil mean MPO index, PSGL1 P-selectin glycoprotein ligand 1, IL1β Interleukin 1 beta, IL8 Interleukin 8, TNFα Tumor Necrosis Factor-Alpha, IL17 Interleukin 17, SLPI Secretory Leukocyte Peptidase Inhibitor
  3. *Statistically significant. Bonferroni correction was used to counteract multiple comparisons between certain categories. Each individual hypothesis was tested at α = 0.05/3 = 0.0167