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Table 3 MPXI and biochemical measurements of the study cohorts

From: Neutrophil activation and neutrophil derived neutrophil extracellular trap formation in patients with coronary artery ectasia

 

CAE

CAD

CON

p value

CAE vs CAD

CAE vs CON

CAD vs CON

Number of patients

30

30

30

    

MPXI

1.02 ± 3.01

3.22 ± 3.03

3.52 ± 4.25

0.013*

0.016*

0.007*

0.745

PSGL1, ng/mL

581.07 ± 162.45

450.76 ± 166.43

379.93 ± 114.75

0.000*

0.001*

0.000*

0.070

E-selectin, ng/mL†

6.49(2.65–17.82)

4.74(1.91–14.32)

3.06(1.45–4.86)

0.036*

0.401

0.011*

0.082

L-selectin, ng/mL

1186.86 ± 356.62

1118 ± 631.53

801.05 ± 190.33

0.002*

0.539

0.001*

0.006*

IL1β, pg/mL† (%)

46.1 ± 121.09 (73.3)

19.72 ± 30.24 (46.7)

4.14 ± 14.79 (16.7)

0.000 (0.000*)

0.296 (0.035)

0.000* (0.000*)

0.018* (0.012*)

IL8, pg/mL† (%)

20.38 ± 88.5 (10)

0.54 ± 2.93 (3.3)

0 ± 0 (0)

0.161 (0.160)

   

TNFα, pg/mL† (%)

1.58 ± 8.56 (6.7)

0.15 ± 0.8 (3.3)

0 ± 0 (0)

0.360 (0.355)

   

IL17, pg/mL† (%)

3.21 ± 17.37 (6.7)

7.36 ± 26.2 (16.7)

0.29 ± 1.59 (3.3)

0.169 (0.168)

   

dsDNA, ng/mL†

284.31(258.33–449.91)

225.12(203.34–257.13)

247.37(231.04–273.01)

0.000*

0.000*

0.001*

0.041*

SLPI, ng/mL

52.24 ± 18.41

44.47 ± 14.57

40.02 ± 6.80

0.004*

0.207

0.005*

0.352

  1. Pearson’s chi-square test was used for frequency differences between categories. ANOVA or Kruskal-Wallis H test (†) was used for continuous variables, LSD or Dunnett T3 was used for multiple comparisons
  2. CAE Coronary artery ectasia, CAD Coronary artery disease, CON Normal coronary artery group, MPXI Intra-neutrophil mean MPO index, PSGL1 P-selectin glycoprotein ligand 1, IL1β Interleukin 1 beta, IL8 Interleukin 8, TNFα Tumor Necrosis Factor-Alpha, IL17 Interleukin 17, SLPI Secretory Leukocyte Peptidase Inhibitor
  3. *Statistically significant. Bonferroni correction was used to counteract multiple comparisons between certain categories. Each individual hypothesis was tested at α = 0.05/3 = 0.0167