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Table 4 Pre- and postprocedural regimens, complications and outcomes

From: Systematic review on left atrial appendage closure with the LAmbre device in patients with non-valvular atrial fibrillation

 Major procedure-related
complications (n= / %)
Minor procedure-related
complications (n= / %)
Follow up time / Outcome (AE) (n= / %)
Chen et al. (2019) [21]Total: n = 0 / 0%0%6 months:
Total: n = 0 / 0%;
Stroke/TIA: n = 0 / 0%;
TFD: n = 0 / 0%;
RF > 5 mm: n = 0 / 0%;
Major Bleeding: n = 0 / 0%;
Device embolization: n = 0 / 0%
RF < 5 mm: n = 9 / 30.0%;
Minor Bleeding: n = 0 / 0%
Feng et al. (2019) [22]Total: n = 1 / 5.9%;
Death: n = 0 / 0%;
PerTam: n = 1 / 5.9%
n = 2 / 11.8% (haematoma)12 months:
Total: n = 0 / 0%;
Stroke/TIA: n = 0 / 0%;
TFD: n = 0 / 0%;
RF > 5 mm: n = 0 / 0%;
Major Bleeding: n = 0 / 0%;
Device embolization: n = 0 / 0%
RF < 5 mm: n = 2 / 11.8%;
Minor Bleeding: n = 0 / 0%;
n = 1 / 5.9% sudden cardiac death at 545 days
Reinsch et al. (2018) [19]Total: n = 0 / 0%;
Death: n = 0 / 0%
0%6 months:
Total: n = 0 / 0%;
Stroke/TIA: 0%;
TFD: 0%;
RF > 5 mm: 0%;
Major Bleeding: n = 0 / 0%;
Device embolization: n = 0 / 0%
RF < 5 mm: 0%;
Minor Bleeding: n = 0 / 0%
Park et al. (2018) [18]Total: n = 4 / 6.7%;
Death: n = 1 / 1.7%;
PerTam: n = 3 / 5.0%;
PerTam requiring surgery with fatal outcome: n = 1 / 1.7%;
Pseudoaneurysm of right AFC requiring surgical repair: n = 1 / 1.7%
0%12 months:
Total: n = 5 / 6.7%;
Stroke/TIA: n = 2 / 1.6%;
TFD: 0%;
RF > 5 mm: n = 3 / 5%a;
Major bleeding: 0%;
Device embolization: n = 0 / 0%
RF < 5 mm: n = 14 / 24.6%;
Minor bleeding: n = 5 / 5%
Death unrelated to LAAC: 3%
Kleinecke et al. (2018) [17]Total: n = 0 / 0%;
Death: n = 0 / 0%
0%N/A
Cruz-Gonzalez et al. (2017) [20]Total: n = 0 / 0%;
Death: n = 0 / 0%
0%N/A
Chen et al. (2018) [9]Total: n = 0 / 0%;
Death: n = 0 / 0%
0%6 months:
Total: n = 0 / 0%;
Stroke/TIA: 0%;
TFD: 0%;
RF > 5 mm: 0%;
Major Bleeding: n = 0 / 0%;
Device embolization: n = 0 / 0%
Zhou et al. (2017) [16]Total: n = 0 / 0%;
Death: n = 0 / 0%
0%N/A
Huang et al. (2017) [15]Total: n = 5 / 3.3%;
Death: n = 0 / 0%;
PerTam: n = 2 / 1.3;
Stroke: n = 1 / 0.7%;
Major bleeding: n = 1 / 0.7%
n = 4 / 2.6%
(Femoral hematoma: n = 2;
Arteriovenous fistula: n = 1
Pseudoaneurysm; n = 1)
12 months:
Total: n = 5 / 3.9%;
Stroke: n = 3 / 2.0%;
TFD: n = 2 / 1.3%;
RF > 5 mm: 0%;
Major Bleeding: n = 0 / 0%;
Device embolization: n = 0 / 0%
Death unrelated to LAAC: n = 1 / 1.3%
Available TEE at 12 months:
n = 121
No RF: n = 102 / 84.3%;
RF 1–3 mm: n = 18 / 14.9%;
RF > 3 mm: n = 1 / 0.8%
Jie et al. (2016) [14]N/AN/AN/A
Total /
Overall mean
Total: n = 10 / 2.9%;
Death: n = 1 / 0.3%;
PerTam: n = 6 / 1.7%;
Stroke: n = 1 / 0.3%;
Major bleeding / Vascular complications: n = 2 / 0.6%
Total: n = 6 / 1.7%Total: n = 10 / 3.3%;
Stroke/TIA: n = 5 / 1.7%;
TFD: n = 2 / 0.7%;
RF > 5 mm: n = 3 / 1.0%;
Major Bleeding: n = 0 / 0%;
Device embolization: n = 0 / 0%
  1. a: After the detection of RF > 5 mm at TEE at 1 month (3 cases), DAPT was switched to OAC. In 2 patients with persisting RF > 5 mm after 12 months, successful percutaneous closure of the leak with an Amplatzer vascular plug was undertaken
  2. Abbreviations
  3. AE: adverse events
  4. AFC: Arteria femoralis communis
  5. DAPT: dual antiplatelet therapy (aspirin plus clopidogrel)
  6. N/A Not available
  7. PC Pericardiocentesis
  8. PE Pericardial effusion
  9. PerTam Pericardial tamponade
  10. RF Residual flow
  11. TFD Thrombus formation on the device