Serum amyloid a protein as a potential biomarker in predicting acute onset and association with in-hospital death in acute aortic dissection

Table 5 Diagnostic value of SAA and its combinations with CRP and D-Dimer for AAD patients

	AUC	95%CI	P-value	cut-off	Sensitivity (%)	Specificity (%)
AAD	0.942	0.902–0.981	< 0.001	0.427	0.908	0.937
TAAD	0.939	0.873–1.004	< 0.001	0.427	0.919	0.937
TBAD	0.937	0.883–0.990	< 0.001	0.462	0.881	0.937
Combination
SAA + CRP	0.977	0.955–0.999	< 0.001	–	0.944	0.938
SAA + D-Dimer	0.900	0.838–0.963	< 0.001	–	0.848	0.938
Death
SAA (death v.s. survival)	0.732	0.612–0.853	0.001	4.998	0.739	0.625
CRP (death v.s. survival)	0.826	0.709–0.942	< 0.001	82.55	0.789	0.771
D-Dimer (death v.s. survival)	0.715	0.562–0.869	0.006	1.945	0.700	0.739
NE% (death v.s. survival)	0.678	0.549–0.808	0.017	72.976	0.857	0.491

Note, AAD acute aortic dissection, TAAD type A aortic dissection, TBAD type B aortic dissection, SAA serum amyloid A, CRP C reactive protein, AUC area under the curve, NE% neutrophil to white blood cell ratio

ISSN: 1471-2261