Table 1 Baseline characteristics of study population
Variables | Total (n = 116) | Normal diastolic function (n = 92) | Diastolic dysfunction (n = 24) | p-value |
|---|---|---|---|---|
Age (years) | 27.46 ± 13.52 | 26.13 ± 10.17 | 32.54 ± 21.70 | 0.171 |
Female gender | 67 (57.76%) | 54 (58.70%) | 13 (54.17%) | 0.689 |
Body weight (kg) | 47.46 ± 10.02 | 48.28 ± 10.38 | 44.29 ± 7.91 | 0.082 |
Body surface area (m2) | 1.43 ± 0.19 | 1.44 ± 0.20 | 1.37 ± 0.16 | 0.101 |
SBP (mmHg) | 109.62 ± 14.88 | 109.97 ± 12.51 | 108.29 ± 22.04 | 0.723 |
DBP (mmHg) | 61.56 ± 11.50 | 62.89 ± 11.23 | 56.46 ± 11.32 | 0.014 |
Heart rate (bpm) | 83.11 ± 11.72 | 84.80 ± 11.85 | 76.63 ± 8.65 | 0.002 |
Homozygous beta thalassemia | 14 (12.07%) | 7 (7.61%) | 7 (29.17%) | 0.009 |
Hemoglobin E/beta thalassemia | 102 (87.93%) | 85 (92.39%) | 17 (70.83%) | 0.009 |
Splenectomy (n = 116) | 28 (24.13%) | 18 (19.56%) | 10 (41.67%) | 0.026 |
Transfusion dependent | 95 (81.90%) | 77 (83.70%) | 18 (75.00%) | 0.374 |
Total transfusion in 1 year (ml); median (IQR) | 175.41 ± 61.13 4 (4–4) | 177.74 ± 64.40 4 (4–4) | 176.63 ± 45.90 4 (3–4) | 0.944 |
Diabetes mellitus | 11 (9.48%) | 8 (8.70%) | 3 (12.50%) | 0.695 |
Hypothyroidism | 11 (9.48%) | 7 (7.61%) | 4 (16.67%) | 0.235 |
Hypertension | 1 (0.86%) | 0 (0.00%) | 1 (4.17%) | 0.207 |
Medication use | ||||
 - Deferiprone | 57 (49.14%) | 46 (50.00%) | 11 (45.83%) | 0.716 |
 - Deferasirox | 43 (37.07%) | 33 (35.87%) | 10 (41.67%) | 0.601 |
 - Deferoxamine | 39 (33.62%) | 34 (36.97%) | 5 (20.83%) | 0.136 |
 - Beta blockers | 7 (6.03%) | 4 (4.35%) | 3 (12.50%) | 0.154 |
 - ACEI/ARB | 2 (1.72%) | 1 (1.09%) | 1 (4.17%) | 0.372 |
 - Statin | 2 (1.72%) | 1 (1.09%) | 1 (4.17%) | 0.372 |
 - Diuretics | 2 (1.72%) | 1 (1.09%) | 1 (4.17%) | 0.372 |
 - Aspirin | 14 (12.07%) | 10 (10.87%) | 4 (16.67%) | 0.484 |
Hemoglobin (g/dl) | 8.48 ± 1.21 | 8.53 ± 1.20 | 8.28 ± 1.27 | 0.361 |
Hematocrit | 26.33 ± 3.26 | 26.44 ± 3.22 | 25.89 ± 3.44 | 0.467 |
Creatinine (mg/dl) | 0.64 ± 0.17 | 0.64 ± 0.17 | 0.66 ± 0.17 | 0.462 |
Ferritin (mcg/l) | 1440.0 (678.0–2575.50) | 1411.00 (596.00–2411.00) | 1502.50 (824.50–2694.00) | 0.424 |
Liver iron concentration (mg Fe/g dry weight) | 7.40 (3.65–15.45) | 7.15 (2.95–14.55) | 8.30 (4.90–23.75) | 0.116 |