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Table 3 Changes in Arterial Inflammation Activity: Index Vessel Analysis

From: Effects of ezetimibe/simvastatin 10/10 mg versus Rosuvastatin 10 mg on carotid atherosclerotic plaque inflammation

Characteristics Ezetimibe /simvastatin (n = 25) Rosuvastatin (n = 25) p-value between groups
MDS TBR of index carotid artery
 Baseline 2.37 ± 0.46 2.23 ± 0.41 0.271
 Follow-up 2.07 ± 0.29 2.09 ± 0.46 0.889
 Nominal change −0.30 ± 0.43 −0.15 ± 0.40 0.197
p-value compared with baseline 0.002 0.077  
 Percent change (primary endpoint) −10.22 ± 17.49 −5.84 ± 15.78 0.357
Whole vessel TBR of index carotid artery
 Baseline 2.00 ± 0.0.39 1.94 ± 0.31 0.537
 Follow-up 1.81 ± 0.26 1.83 ± 0.35 0.772
 Nominal change −0.19 ± 0.38 − 0.11 ± 0.38 0.419
p-value compared with baseline 0.017 0.168  
 Percent change −6.81 ± 19.06 −3.95 ± 17.01 0.579
MDS TBR of aorta
 Baseline 2.58 ± 0.45 2.57 ± 0.45 0.912
 Follow-up 2.27 ± 0.34 2.35 ± 0.46 0.459
 Nominal change −0.31 ± 0.44 −0.21 ± 0.52 0.466
p-value compared with baseline 0.002 0.052  
 Percent change −10.35 ± 16.24 −6.80 ± 18.36 0.473
Whole vessel TBR of aorta
 Baseline 2.47 ± 0.43 2.47 ± 0.45 0.959
 Follow-up 2.19 ± 0.33 2.26 ± 0.45 0.507
 Nominal change −0.29 ± 0.43 −0.20 ± 0.52 0.549
p-value compared with baseline 0.003 0.063  
 Percent change −9.580 ± 16.45 −6.58 ± 19.04 0.526
  1. Nominal change is calculated as follow-up minus baseline, and percent change as (follow-up minus baseline)/baseline×100. MDS Most diseased segment, TBR Tissue blood ratio