Association between the XKR6 rs7819412 SNP and serum lipid levels and the risk of coronary artery disease and ischemic stroke

Table 5 Association of the genotypes and serum lipid levels in controls and CAD and ischemic stroke patients

Genotype	n	TC (mmol/L)	TG (mmol/L)	HDL-C (mmol/L)	LDL-C (mmol/L)	ApoA1 (g/L)	ApoB (g/L)	ApoA1/ ApoB
Control
GG	551	4.35 ± 1.04	1.35 ± 1.70	1.90 ± 0.49	2.74 ± 0.76	1.42 ± 0.28	0.91 ± 0.21	1.66 ± 0.58
GA/AA	92	4.25 ± 1.07	1.54 ± 2.11	1.85 ± 0.50	2.61 ± 0.87	1.38 ± 0.26	0.88 ± 0.21	1.63 ± 0.40
F		1.306	0.987	0.941	2.276	0.924	0.444	0.228
P		0.254	0.321	0.332	0.132	0.337	0.505	0.633
CAD
GG	476	4.55 ± 1.19	1.59 ± 1.00	1.15 ± 0.34	2.82 ± 0.99	1.02 ± 0.32	0.91 ± 0.26	1.23 ± 0.84
GA/AA	112	4.57 ± 1.33	1.92 ± 1.48	1.15 ± 0.34	3.00 ± 1.16	1.06 ± 0.45	0.90 ± 0.28	1.27 ± 0.58
F		0.004	7.267	0.100	2.719	1.411	0.491	0.344
P		0.952	0.007	0.752	0.100	0.235	0.484	0.558
Ischemic stroke
GG	447	4.49 ± 1.15	1.64 ± 1.24	1.23 ± 0.42	2.81 ± 0.87	1.02 ± 0.22	0.89 ± 0.24	1.25 ± 0.47
GA/AA	105	4.73 ± 1.21	1.85 ± 2.17	1.27 ± 0.37	2.92 ± 1.07	1.05 ± 0.26	0.93 ± 0.27	1.26 ± 0.60
F		4.270	1.672	0.887	1.822	0.985	3.254	0.000
P		0.039	0.197	0.347	0.178	0.321	0.072	0.993

Adjusted for sex, age, smoking, drinking, BMI, diabetes, hypertension, hyperlipidemia. TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoA1 apolipoprotein A1, ApoB apolipoprotein B, CAD Coronary artery disease

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