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Table 3 Patient characteristics by MRA discharge prescription

From: Mineralocorticoid receptor antagonist use after hospitalization of patients with heart failure and post-discharge outcomes: a single-center retrospective cohort study

 

Total N = 1500

MRA after Hospitalization n = 375

No MRA after Hospitalization n = 1125

p-value

Demographics

 Age, Mean ± SD

71.9 ± 13.6

69.7 ± 13.6

72.6 ± 13.2

0.0003

 Female

443 (29.5%)

108 (28.8%)

335 (29.8%)

0.7193

 Black

227 (15.1%)

67 (17.9%)

160 (14.2%)

0.0881

 Hispanic

97 (6.5%)

37 (9.9%)

60 (5.3%)

0.0020

Comorbid conditions

 Hypertension

1151 (76.7%)

282 (75.2%)

869 (77.2%)

0.4171

 Atrial fibrillation

792 (52.8%)

202 (53.9%)

590 (52.4%)

0.6328

 Diabetes mellitus

617 (41.1%)

166 (44.3%)

451 (40.1%)

0.1545

 Chronic kidney disease

511 (34.1%)

117 (31.2%)

394 (35.0%)

0.1762

 Malignancy

325 (21.7%)

65 (17.3%)

260 (23.1%)

0.0187

 COPD

244 (16.3%)

57 (15.2%)

187 (16.6%)

0.5181

 Myocardial infarction

241 (16.1%)

61 (16.3%)

180 (16.0%)

0.9031

 Cerebrovascular disease

204 (13.6%)

39 (10.4%)

165 (14.7%)

0.0369

 Peripheral vascular disease

170 (11.3%)

37 (9.9%)

133 (11.8%)

0.3009

 Dementia

141 (9.4%)

30 (8.0%)

111 (9.9%)

0.2834

 Cirrhosis

27 (1.8%)

4 (1.1%)

23 (2.0%)

0.2174

 LVEF %, Mean ± SD

26.4 ± 7.2

23.9 ± 7.0

27.3 ± 7.1

<0.0001

Admission Blood Pressure, Labs, & Home Medications

 Admission Systolic blood pressure, Mean ± SD

130.7 ± 23.8

128.6 ± 23.3

131.4 ± 23.9

0.0475

 Sodium, Mean ± SD

137.4 ± 4.4

137.6 ± 4.1

137.4 ± 4.6

0.3131

 Potassium, Mean ± SD

4.4 ± 0.6

4.4 ± 0.6

4.4 ± 0.6

0.7813

 Creatinine, Mean ± SD

1.2 ± 0.5

1.2 ± 0.5

1.2 ± 0.5

0.6580

 eGFR, Mean ± SD

63.6 ± 24.9

64.6 ± 23.3

63.3 ± 25.4

0.3398

 ACE Inhibitor or ARB

882 (58.8%)

248 (66.1%)

634 (56.4%)

0.0009

 Beta blocker

1095 (73.0%)

298 (79.5%)

797 (70.8%)

0.0011

 Loop diuretic

864 (57.6%)

262 (69.9%)

602 (53.5%)

<0.0001

Discharge Labs & Home Medications

 Creatinine, Mean ± SD

1.2 ± 0.4

1.2 ± 0.4

1.1 ± 0.4

0.0817

 eGFR, Mean ± SD

65.4 ± 24.0

64.7 ± 23.6

65.6 ± 24.1

0.5497

 Potassium, Mean ± SD

4.2 ± 0.4

4.2 ± 0.4

4.2 ± 0.4

0.9968

 ACE Inhibitor or ARB

975 (65.0%)

279 (74.4%)

696 (61.9%)

<0.0001

 Beta blocker

1184 (78.9%)

336 (89.6%)

848 (75.4%)

<0.0001

 Loop diuretic

1022 (68.1%)

315 (84.0%)

707 (62.8%)

<0.0001

Primary Service*

 Cardiology

668 (44.5%)

203 (54.1%)

465 (41.3%)

<0.0001

 Medicine

411 (27.4%)

82 (21.9%)

329 (29.2%)

0.006

 Other

395 (26.3%)

86 (22.9%)

309 (27.5%)

0.08

  1. Abbreviations: SD Standard Deviation, COPD Chronic Obstructive Pulmonary Disease, ACE angiotensin converting enzyme, ARB Angiotensin Receptor Blocker, eGFR estimated glomerular filtration rate (ml/min/1.73 m2), LVEF left ventricular ejection fraction. *Primary Service totals do not add up to 100% due to missing data (~2% of admissions).