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Table 3 Prevalence of major adverse cardiovascular events and all-cause mortality and electrocardiographic parameters according to fatty acid-binding protein 4 level

From: Plasma fatty acid-binding protein 4 (FABP4) level is associated with abnormal QTc interval in patients with stable angina and chronic kidney disease

Parameter

First tertile

Second tertile

Third tertile

P for trend

FABP4 (ng/mL)

≤7.4

7.5–16.25

> 16.25

 

Number

132

133

132

 

LVEF (%)

62.7 ± 11.5

62.9 ± 11.1

57.9 ± 12.8

0.001

Hs-CRP (mg/L)

1.3 (0.4–4.6)

1.8 (0.7–4.0)

4.4 (1.5–10.1)

0.043

White blood cell count (×109/L)

8.212 ± 2.991

8.011 ± 3.322

9.188 ± 4.058

0.356

ECG parameters

 Heart Rate (bpm)

72.0 ± 16.8

74.1 ± 16.2

82.4 ± 16.6

0.001

 PR interval (ms)

168.2 ± 34.0

166.4 ± 33.6

172.7 ± 32.4

0.812

 QRS duration (ms)

95.1 ± 13.4

96.0 ± 18.9

99.5 ± 19.9

0.020

 QT interval (ms)

403.1 ± 39.5

402.1 ± 38.2

399.9 ± 45.0

0.743

 QTc interval (ms)

436.0 ± 30.7

440.2 ± 34.4

461.5 ± 39.2

< 0.0001

Medication (n, %)

 Anti-arrhythmic medication

34 (25.8)

38 (28.6)

41 (31.1)

0.634

 Beta-blockers

22 (16.7)

23 (17.3)

23 (17.4)

0.985

 Diuretics

12 (9.1)

6 (4.5)

10 (7.6)

0.333

 Statins

38 (28.8)

36 (27.1)

33 (25.0)

0.786

Hypertension (n, %)

77 (58.3)

99 (74.4)

109 (82.6)

< 0.0001

Dyslipidemia (n, %)

84 (63.6)

92 (69.2)

83 (62.9)

0.501

Diabetes (n, %)

31 (23.5)

53 (39.9)

82 (62.1)

< 0.0001

Heart failure (n, %)

14 (10.6)

15 (11.3)

36 (27.3)

0.0002

Chronic kidney diseasea (n, %)

36 (27.3)

58 (43.6)

105 (79.6)

< 0.0001

MACEs (n, %)

41 (31.1)

47 (35.3)

66 (50.0)

0.004

All-cause Mortality (n, %)

1 (0.8)

4 (3.0)

9 (6.8)

0.026

Non-fatal outcome (n, %)

 Heart failure

6 (4.6)

6 (4.5)

15 (11.4)

0.028

 Target lesion revascularization

28 (21.2)

32 (24.1)

31 (23.5)

0.562

 Recurrent myocardial Infarction

6 (4.6)

5 (3.8)

11 (8.3)

0.180

  1. Data are expressed as mean ± SD, number (percentage), or median (interquartile range). FABP4 fatty acid-binding protein 4, LVEF left ventricular ejection fraction, Hs-CRP high-sensitivity C-reactive protein, ECG electrocardiography, QTc corrected QT, MACEs major adverse cardiovascular events. aChronic kidney disease was defined as an eGFR< 60 mL/min/1.73 m2