Table 6 SSEE Analysis with Bootstrapped DerSimonian-Laird random-effects model calculated by STATA
STUDY | Overall | Subgroup: VHD | Subgroup: TAVI | Sensitivity Test | Harbord’s modified test | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
RR | 95%CI | Weight(%) | RR | 95%CI | Weight(%) | RR | 95%CI | Weight(%) | RR | 95%CI | p-value | |
ARISTOTLE, 2015 | 0.699 | 0.510, 0.959 | 23.77 | 0.699 | 0.510, 0.959 | 26.35 | 0.661 | 0.415, 1.054 | 0.97 | |||
ENGAGE AF-TIMI 48, 2017 | 0.838 | 0.595, 1.181 | 22.99 | 0.838 | 0.595, 1.181 | 25.42 | 0.622 | 0.412, 0.939 | ||||
RE-LY, 2016 | 0.387 | 0.273, 0.548 | 22.85 | 0.387 | 0.273, 0.548 | 25.25 | 0.772 | 0.633, 0.941 | ||||
ROCKET AF, 2014 | 0.81 | 0.536, 1.224 | 20.95 | 0.81 | 0.536, 1.224 | 22.99 | 0.633 | 0.417, 0.960 | ||||
Seeger, 2017 | 0.398 | 0.105, 1.508 | 5.64 | 0.398 | 0.105, 1.508 | 54.56 | 0.685 | 0.479, 0.979 | ||||
Geis, 2018 | 2.234 | 0.415, 12.026 | 3.8 | 2.234 | 0.415, 12.026 | 45.44 | 0.636 | 0.456, 0.886 | ||||
Overall | 0.665 | 0.468, 0.945 | 100 | 0.652 | 0.457, 0.930 | 100 | 0.872 | 0.159, 4.767 | 100 | 0.664 | 0.474, 0.931 | |
Heterogeneity Measures | Value | df | p-value | Value | df | p-value | Value | df | p-value | |||
Cochran’s Q | 14.59 | 5 | 0.012 | 12.12 | 3 | 0.007 | 2.47 | 1 | 0.116 | |||
Heterogeneity Measures | Value (95%CI) | Value (95%CI) | Value (95%CI) | |||||||||
I2 (%) | 62.7 | 9.41, 84.65 | 75.27 | 31.56, 91.07 | 60.52 | 0.00, 90.80 | ||||||
H2 | 2.68 | 1.10, 6.51 | 4.04 | 1.46, 11.19 | 2.53 | 0.59, 10.87 | ||||||
tau2 (BDL) | 0.109 | 0.098 | 0.916 | |||||||||