Ischemic stroke risk estimation in patients without oral anticoagulation: an observational cohort study based on secondary data from Germany

Table 3 Incidence rates of ischemic stroke, thromboembolic events and bleeding events stratified by CHA₂DS₂-VASc-score in patients with atrial fibrillation and without oral anticoagulation (N = 30,229)

CHA₂DS₂-VASc	N	ischemic strokes				Thrombembolic events				Bleeding
CHA₂DS₂-VASc	N	events	incidence rate (per 100py)	95%-CI		events	incidence rate (per 100py)	95%-CI		events	incidence rate (per 100py)	95%-CI
0	721	1	0.08	0.01	0.55	4	0.31	0.12	0.82	2	0.15	0.04	0.62
1	1881	16	0.48	0.30	0.79	26	0.79	0.54	1.16	11	0.33	0.19	0.60
2	2636	47	1.08	0.82	1.44	83	1.92	1.55	2.37	21	0.48	0.32	0.74
3	4208	85	1.30	1.05	1.60	137	2.10	1.78	2.47	34	0.52	0.37	0.72
4	6394	215	2.31	2.02	2.63	332	3.58	3.22	3.98	84	0.90	0.73	1.11
5	6784	243	2.58	2.28	2.93	390	4.18	3.79	4.60	87	0.92	0.75	1.14
6	4823	200	3.27	2.86	3.75	341	5.62	5.07	6.24	78	1.28	1.02	1.59
7	2066	107	4.18	3.47	5.04	164	6.44	5.55	7.46	31	1.21	0.85	1.71
8	530	33	5.31	3.81	7.39	53	8.58	6.64	11.10	10	1.59	0.86	2.93
9	186	14	7.22	4.36	11.96	23	12.27	8.37	18.0	4	2.03	0.77	5.35
Total	30,229	961	2.20	2.07	2.34	1553	3.55	3.38	3.73	362	0.83	0.75	0.92

Thromboembolic events include ischemic stroke, transient ischemic attack, peripheral arterial embolism, pulmonary embolism, and mesenterial embolism
Bleeding events include intracranial bleeding, gastrointestinal bleeding and acute posthemorrhagic anemia
CI confidence interval, py person-years

ISSN: 1471-2261