Table 1 Baseline characteristics of included studies
Study | Country, recruitment period | No. of patients randomized | Age ±SD/ (range) | Killip class > 1 | eGFR | Intervention Arm | Delivered hydration in intervention groupa | CIN (%) | RRT(%) | In-hospital mortality (%) | HF /APE | Mean LOS (intervention; control) (days) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Maioli et.al.(2011) | Italy, July 2004–December 2008 | 461 | 65.0 ± 12.34 | 20.6% (93/450) | 75.67 ± 21.71 | Biocarbonate Solution: 3 mL/kg in 1 h, starting in the DR, 1 mL/kg per hour for 12 h after PCI, but reduced to 0.5 mL/kg in patients with LVEF≤40% or NYHA class III-IV Normal Saline: 1 mL/kg per hour for 12 h immediately after PCI, but reduced to 0.5 mL/kg in patients with LVEF≤40% or NYHA class III-IV | Mean volume: 1021 ± 196 ml | 20.6%(93/450) | 0.9% (4/450) | 3.5% (16/450) | Unknown | Unknown |
Luo et.al.(2014) | China, August 2009–October 2012 | 216 | 67.0 (57–75) | 35.6% (77/216) | 70.55 ± 22.90 | Normal Saline: 1 mL/kg per hour for 12 h after primary PCI, but reduced to 0.5 mL/kg.hr. in patients with LVEF≤30% or Killip class II-III | Mean rate: 0.75 ml/kg/hour | 27.8% (60/216) | 3.7% (8/216) | 6% (13/216) | 6% (13/216) | 6.8 ± 25.7; 14.4 ± 30.5 |
Jurado-Román et.al.(2015) | Spain, July 2012–November 2013 | 408 | 62.8 ± 13.04 | 14.7% (60/408) | 89 ± 40.97 | Normal Saline: 1 mL/kg/h since the beginning of procedure and during the following 24 h, but reduced to 0.5 mL/kg in patients with LVEF< 40% or Killip class III-IV | Mean volume: 1720 ± 234 ml | 14%(57/408) | 1% (3/303) | 4.81%(15/312) | Unknown | 6; 8.2 |