The interaction effects between TLR4 and MMP9 gene polymorphisms contribute to aortic aneurysm risk in a Chinese Han population

Table 6 Cumulative effect of the interacting factors of TLR4rs1927914-MMP9rs17576 on the risk of AA subtypes^a

No. of interacting genotypes	AAA			TAA			large AA			small AA
No. of interacting genotypes	Controls/cases	P	OR(95%CI)	Controls/cases	P	OR(95%CI)	Controls/cases	P	OR(95%CI)	Controls/cases	P	OR(95%CI)
TLR4rs1927914-MMP9rs17576
0	168/62		1.0(ref.)	168/72		1.0(ref.)	168/53		1.0(ref.)	168/81		1.0(ref.)
1	280/124	0.170	1.293(0.896–1.865)	280/119	0.808	0.957(0.673–1.362)	280/84	0.001	1.002(0.673–1.492)	280/162	0.287	1.196(0.860–1.664)
2	14/15	0.014	2.736(1.222–6.128)	14/13	0.058	2.180(0.973–4.886)	14/16	0.004	3.234(1.456–7.184)	14/14	0.072	2.060(0.936–4.533)
		P_trend = 0.031			P_trend = 0.338			P_trend = 0.079			P_trend = 0.084

^a, P for association was adjusted by age, gender, hypertension, diabetes and dyslipidemia; AA aortic aneurysm, AAA abdominal aortic aneurysm, TAA thoracic aortic aneurysm

ISSN: 1471-2261