Table 4 Adherence comparison to index medication among DOAC users stratified by first day supply and fill method at 12 months of follow-up
Dabigatran | Rivaroxaban | Apixaban | P-value | |
|---|---|---|---|---|
First day supply = 30 days | ||||
PDC, mean (SD) | 0.55 (0.36) | 0.63 (0.36) | 0.66 (0.34) | <.0001 |
≥0.8, n (%) | 3852 (38.56) | 4036 (48.29) | 1424 (52.60) | |
0.5–.079, n (%) | 1349 (13.60) | 1036 (12.40) | 396 (14.63) | |
< 0.5, n (%) | 4746 (47.84) | 3285 (39.31) | 887 (32.77) | |
First day supply = 90 days | ||||
PDC, mean (SD) | 0.72 (0.30) | 0.79 (0.28) | 0.84 (0.24) | <.0001 |
≥0.8, n (%) | 845 (56.48) | 824 (66.83) | 458 (73.87) | |
0.5–.079, n (%) | 198 (13.24) | 147 (11.92) | 73 (11.77) | |
< 0.5, n (%) | 453 (30.28) | 262 (21.25) | 89 (14.35) | |
Filled via mail pharmacy (1st fill) | ||||
PDC, mean (SD) | 0.71 (0.31) | 0.79 (0.28) | 0.84 (0.24) | <.0001 |
≥0.8, n (%) | 755 (56.72) | 509 (66.10) | 328 (73.71) | |
0.5–.079, n (%) | 169 (12.70) | 100 (12.99) | 58 (13.03) | |
< 0.5, n (%) | 407 (30.58) | 161 (20.91) | 59 (13.26) | |
Filled via retail pharmacy (1st fill) | ||||
PDC, mean (SD) | 0.55 (0.36) | 0.63 (0.36) | 0.67 (0.34) | <.0001 |
≥0.8, n (%) | 3907 (38.70) | 4522 (48.59) | 1616 (53.62) | |
0.5–.079, n (%) | 1377 (13.64) | 1164 (12.51) | 439 (14.57) | |
< 0.5, n (%) | 4811 (47.66) | 3620 (38.90) | 959 (31.82) | |