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Table 2 associations of clinical and healthcare provider factors with suboptimal statin adherence and non-persistence in patients post ASCVD discharge

From: Long-term statin adherence in patients after hospital discharge for new onset of atherosclerotic cardiovascular disease: a population-based study of real world prescriptions in Taiwan

Variable Adjusted odds ratio (95% CI) Adjusted coefficient (SE) Adjusted hazard ratio (95% CI)
Clinical factors
 Patient demographics
  Age at index date > 75 vs. ≤75 (y) 1.10 (1.08–1.12) −0.026 (0.002) 1.11 (1.09–1.13)
  Female vs. male 0.96 (0.95–0.98) 0.007 (0.002) 1.00 (0.99–1.02)
Previous statin use
  Used one year prior to ASCVD 0.72 (0.71–0.74) 0.069 (0.002) 0.89 (0.86–0.93)
  Used during hospitalization 0.93 (0.91–0.95) 0.015 (0.002) 0.74 (0.72–0.75)
Diagnosis of ASCVD events
 Ischemic stroke Ref. (0.98–1.07) Ref.   Ref.  
 AMI without PTCA/CABG 1.03 (0.63–0.67) 0.002 (0.004) 1.06 (1.02–1.11)†
 AMI receiving revascularization 0.65 (0.69–0.73) 0.087 (0.003) 0.69 (0.67–0.71)‡
CHD receiving revascularization 0.71 (0.98–1.07) 0.075 (0.003) 0.71 (0.69–0.73)‡
Comorbidities one year before ASCVD
 Renal disease 1.29 (1.25–1.33) −0.043 (0.003) 1.21 (1.17–1.24)
 Liver disease 1.10 (1.07–1.14) −0.013 (0.003) 1.09 (1.06–1.12)
 Depression 1.10 (1.06–1.14) −0.015 (0.004) 1.09 (1.06–1.12)
 COPD 1.07 (1.04–1.10) −0.012 (0.003) 1.07 (1.04–1.09)
 Dementia 1.06 (1.01–1.12) −0.018 (0.005) 1.05 (1.00–1.10)
 Transient ischemic attack 0.99 (0.95–1.03) 0.002 (0.004) 1.01 (0.97–1.05)
 Ischemic heart disease 0.99 (0.97–1.01) 0.004 (0.002) 0.98 (0.96–1.00)
 Cancer 1.00 (0.96–1.03) 0.004 (0.003) 0.98 (0.95–1.01)
 Hyperlipidemia 0.93 (0.91–0.95) 0.022 (0.002) 0.93 (0.91–0.95)
Medications one year before ASCVD
 Insulin 1.15 (1.12–1.18) −0.020 (0.002) 1.11 (1.08–1.13)
 Digitalis 1.12 (1.08–1.17) −0.022 (0.004) 1.10 (1.06–1.15)
 OADs 1.05 (1.03–1.07) −0.007 (0.002) 1.09 (1.07–1.11)
 ACEIs 1.05 (1.03–1.07) −0.009 (0.002) 1.05 (1.03–1.07)
 Diuretics 1.05 (1.03–1.07) −0.011 (0.002) 1.05 (1.03–1.07)
 CCBs 1.02 (1.00–1.04) −0.003 (0.002) 1.04 (1.03–1.06)
 Anticoagulants 0.99 (0.96–1.02) 0.003 (0.003) 0.95 (0.93–0.98)
 β-blockers 0.95 (0.93–0.96) 0.008 (0.002) 0.97 (0.95–0.98)
 ARBs 0.95 (0.93–0.97) 0.008 (0.002) 0.96 (0.94–0.97)
 Antiplatelet agents 0.94 (0.92–0.96) 0.010 (0.002) 0.93 (0.92–0.95)
Index statin used
 Dosage: moderate vs. low 0.96 (0.94–0.97) 0.010 (0.002) 0.95 (0.93–0.96)
 Dosage: high vs. low 1.03 (0.98–1.07) 0.000 (0.004) 0.97 (0.94–1.01)
 High potency vs. others 0.91 (0.89–0.93) 0.020 (0.002) 0.92 (0.90–0.94)
Healthcare provider factors
 Accreditation level of statin prescribing healthcare organization
  Primary care clinic Ref.   Ref.   Ref.  
  District hospital 0.88 (0.83–0.93) −0.003 (0.006) 0.85 (0.81–0.90)
  Regional hospital 0.78 (0.74–0.83) 0.020 (0.006) 0.82 (0.78–0.86)
  Medical center 0.60 (0.56–0.63) 0.070 (0.006) 0.61 (0.58–0.64)
  Other hospital 0.76 (0.71–0.82) 0.033 (0.007) 0.80 (0.75–0.86)
Geographic location of statin prescribing healthcare organization
 Eastern region Ref.   Ref.   Ref.  
 Taipei region 0.90 (0.86–0.94) 0.037 (0.004) 0.89 (0.86–0.93)
 Northern region 0.87 (0.82–0.91) 0.030 (0.005) 0.87 (0.83–0.91)
 Central region 1.00 (0.95–1.05) −0.001 (0.004) 0.97 (0.92–1.01)
 Southern region 0.83 (0.79–0.87) 0.044 (0.004) 0.81 (0.77–0.84)
 Kao-Ping region 0.84 (0.80–0.88) 0.033 (0.004) 0.84 (0.81–0.88)
Specialty of statin prescribing physician
 Others (exclude all below) Ref.   Ref.   Ref.  
 Cardiovascular medicine 0.53 (0.50–0.56) 0.109 (0.006) 0.62 (0.59–0.65)
 Cardiovascular surgery 0.53 (0.49–0.57) 0.107 (0.007) 0.65 (0.61–0.69)
 Metabolism and Endocrinology 0.59 (0.55–0.63) 0.115 (0.006) 0.58 (0.55–0.62)
 Neurology 0.68 (0.65–0.72) 0.065 (0.006) 0.80 (0.76–0.84)
 Internal medicine 0.77 (0.73–0.82) 0.040 (0.006) 0.89 (0.85–0.93)
 Family medicine 0.84 (0.77–0.92) 0.020 (0.008) 0.92 (0.86–0.99)
Year of index statin prescription
 2006 Ref.   Ref.   Ref.  
 2007 0.89 (0.86–0.91) 0.024 (0.003) 0.91 (0.89–0.94)
 2008 0.83 (0.81–0.85) 0.036 (0.003) 0.86 (0.84–0.88)
 2009 0.76 (0.74–0.78) 0.048 (0.003) 0.80 (0.78–0.82)
 2010 0.72 (0.70–0.74) 0.055 (0.003) 0.75 (0.73–0.77)
 2011 0.69 (0.67–0.71) 0.059 (0.003) 0.73 (0.71–0.75)
 2012 0.49 (0.47–0.51) 0.100 (0.003) 0.69 (0.66–0.72)
  1. p-value < 0.05;p-value < 0.001. All factors were included for adjustment