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Table 1 Common pathways between CAD and plasma lipid levels

From: Integrative genomic analysis identified common regulatory networks underlying the correlation between coronary artery disease and plasma lipid levels

Pathway nameP-CADP-HDLP-LDLP-TCP-TG
Positive regulation of cholesterol storage3.99 × 10−098.07 × 10−229.38 × 10−034.45 × 10− 032.03 × 10− 12
Apolipoprotein binding1.10 × 10−068.25 × 10−291.82 × 10−051.99 × 10− 185.35 × 10− 09
low-density lipoprotein particle8.32 × 10−092.13 × 10− 051.23 × 10− 108.16 × 10− 062.10 × 10− 03
Lipoprotein catabolic process2.72 × 10− 099.06 × 10− 123.30 × 10− 126.44 × 10− 111.12 × 10− 07
Chylomicron2.31 × 10− 063.32 × 10−116.99 × 10− 105.61 × 10− 079.59 × 10− 21
Cholesterol homeostasis*9.61 × 10− 084.83 × 10− 176.99 × 10− 153.49 × 10− 264.17 × 10− 12
Reverse cholesterol transport4.13 × 10− 063.76 × 10− 238.02 × 10−051.25 × 10− 202.54 × 10− 07
Triglyceride homeostasis3.65 × 10− 073.32 × 10− 186.03 × 10− 065.40 × 10− 102.23 × 10−20
Lipase6.16 × 10− 072.82 × 10− 122.99 × 10− 021.22 × 10− 051.77 × 10− 08
Chylomicron mediated lipid transport*4.81 × 10− 066.34 × 10− 145.37 × 10−121.72 × 10− 171.16 × 10− 18
Lipoprotein metabolism *7.59 × 10− 081.10 × 10− 176.29 × 10−118.01 × 10− 192.25 × 10− 18
  1. The asterisk (*) marked pathways maintained significance after multiple testing corrections across all five traits