Table 1 Common pathways between CAD and plasma lipid levels
Pathway name | P-CAD | P-HDL | P-LDL | P-TC | P-TG |
|---|---|---|---|---|---|
Positive regulation of cholesterol storage | 3.99 × 10−09 | 8.07 × 10−22 | 9.38 × 10−03 | 4.45 × 10− 03 | 2.03 × 10− 12 |
Apolipoprotein binding | 1.10 × 10−06 | 8.25 × 10−29 | 1.82 × 10−05 | 1.99 × 10− 18 | 5.35 × 10− 09 |
low-density lipoprotein particle | 8.32 × 10−09 | 2.13 × 10− 05 | 1.23 × 10− 10 | 8.16 × 10− 06 | 2.10 × 10− 03 |
Lipoprotein catabolic process | 2.72 × 10− 09 | 9.06 × 10− 12 | 3.30 × 10− 12 | 6.44 × 10− 11 | 1.12 × 10− 07 |
Chylomicron | 2.31 × 10− 06 | 3.32 × 10−11 | 6.99 × 10− 10 | 5.61 × 10− 07 | 9.59 × 10− 21 |
Cholesterol homeostasis* | 9.61 × 10− 08 | 4.83 × 10− 17 | 6.99 × 10− 15 | 3.49 × 10− 26 | 4.17 × 10− 12 |
Reverse cholesterol transport | 4.13 × 10− 06 | 3.76 × 10− 23 | 8.02 × 10−05 | 1.25 × 10− 20 | 2.54 × 10− 07 |
Triglyceride homeostasis | 3.65 × 10− 07 | 3.32 × 10− 18 | 6.03 × 10− 06 | 5.40 × 10− 10 | 2.23 × 10−20 |
Lipase | 6.16 × 10− 07 | 2.82 × 10− 12 | 2.99 × 10− 02 | 1.22 × 10− 05 | 1.77 × 10− 08 |
Chylomicron mediated lipid transport* | 4.81 × 10− 06 | 6.34 × 10− 14 | 5.37 × 10−12 | 1.72 × 10− 17 | 1.16 × 10− 18 |
Lipoprotein metabolism * | 7.59 × 10− 08 | 1.10 × 10− 17 | 6.29 × 10−11 | 8.01 × 10− 19 | 2.25 × 10− 18 |