Association of Klotho gene polymorphism with hypertension and coronary artery disease in an Iranian population

Table 3 Association Klotho C1818T polymorphic genotypes and the risk of CAD and hypertension with multinomial regression

Model of inheritance		H-Tens vs. Ctrl		CAD + H-Tens vs. Ctrl		CAD vs. Ctrl
Model of inheritance		P-value	Adjusted OR [95% CI]	P-value	Adjusted OR [95% CI]	P-value	Adjusted OR [95% CI]
C1818T
Total subjects	(CT + CC) vs. (TT)¹	0.02*	0.07 [0.008–0.69]	0.17	0.35 [0.08–1.56]	0.88	1.09 [0.33–3.64]
Total subjects	(CC) vs. (CT + TT)²	0.27	1.52 [0.71–3.27]	0.14	0.59 [0.29–1.19]	0.34	1.46 [0.67–3.20]
Age<57	(CT + CC) vs. (TT)	0.53	0.53 [0.08–3.44]	0.19	0.19 [0.01–2.30]	0.86	1.17 [0.19–7.08]
Age<57	(CC) vs. (CT + TT)	0.15	2.13 [0.76–6.00]	0.99	1.00 [0.37–2.67]	0.30	1.82 [0.59–5.59]
Age ≥ 57	(CT + CC) vs. (TT)	0.19	0.56 [0.83–5.32]	0.86	0.83 [0.09–7.34]	0.61	1.66 [0.23–11.66]
Age ≥ 57	(CC) vs. (CT + TT)	0.64	0.74 [0.21–2.58]	0.04*	0.31 [0.10–0.95]	0.92	1.06 [0.32–3.59]

CAD = Coronary artery disease; H-Tens = Hypertension; CAD + H-Ten = Coronary artery disease and hypertension; Ctrl = Control; OR = Odds ratio; 95% CI = Confidence interval. *Significant difference (P<0.05)
¹Recessive model; ²Dominant model: Adjusted for age, sex, BMI, and Cr using the multinomial regression model. *Significant difference (P<0.05)

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