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Table 3 Association Klotho C1818T polymorphic genotypes and the risk of CAD and hypertension with multinomial regression

From: Association of Klotho gene polymorphism with hypertension and coronary artery disease in an Iranian population

Model of inheritance H-Tens vs. Ctrl CAD + H-Tens vs. Ctrl CAD vs. Ctrl
P-value Adjusted OR [95% CI] P-value Adjusted OR [95% CI] P-value Adjusted OR [95% CI]
C1818T
 Total subjects (CT + CC) vs. (TT)1 0.02* 0.07 [0.008–0.69] 0.17 0.35 [0.08–1.56] 0.88 1.09 [0.33–3.64]
(CC) vs. (CT + TT)2 0.27 1.52 [0.71–3.27] 0.14 0.59 [0.29–1.19] 0.34 1.46 [0.67–3.20]
 Age<57 (CT + CC) vs. (TT) 0.53 0.53 [0.08–3.44] 0.19 0.19 [0.01–2.30] 0.86 1.17 [0.19–7.08]
(CC) vs. (CT + TT) 0.15 2.13 [0.76–6.00] 0.99 1.00 [0.37–2.67] 0.30 1.82 [0.59–5.59]
 Age ≥ 57 (CT + CC) vs. (TT) 0.19 0.56 [0.83–5.32] 0.86 0.83 [0.09–7.34] 0.61 1.66 [0.23–11.66]
(CC) vs. (CT + TT) 0.64 0.74 [0.21–2.58] 0.04* 0.31 [0.10–0.95] 0.92 1.06 [0.32–3.59]
  1. CAD = Coronary artery disease; H-Tens = Hypertension; CAD + H-Ten = Coronary artery disease and hypertension; Ctrl = Control; OR = Odds ratio; 95% CI = Confidence interval. *Significant difference (P<0.05)
  2. 1Recessive model; 2Dominant model: Adjusted for age, sex, BMI, and Cr using the multinomial regression model. *Significant difference (P<0.05)