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Table 2 Comparison of genotype and allele frequency of Klotho C1818T among the four groups

From: Association of Klotho gene polymorphism with hypertension and coronary artery disease in an Iranian population

Groups
SNPs
(1) H-Tens
(N = 60)
(2) CAD + H-Tens
(N = 95)
(3) CAD
(N = 61)
(4) Ctrl
(N = 70)
P-value
1 vs. 4 2 vs. 4 3 vs. 4 1&2&3&4
C1818T (rs564481)
Total Subjects
 CC 23 (38%) 53 (56%) 21 (34%) 33 (47%) 0.50 0.27 0.33 0.13
 CT 31 (52%) 37 (39%) 32 (52%) 29 (41%)
 TT 6 (10%) 5 (5%) 8 (13%) 8 (11%)
 Allele C 77 (64%) 143 (75%) 74 (61%) 95 (68%) 0.45 0.14 0.22 0.03*
 Allele T 43 (36%) 47 (25%) 48 (39%) 45 (32%)
 HWE X2 0.92 0.2 0.6 0.18  
P-value 0.41 0.79 0.59 0.78
C1818T (rs564481)
Age < 57 years
 CC 14 (41%) 26 (62%) 11 (42%) 25 (58%) 0.28 0.39 0.42 0.28
 CT 17 (50%) 15 (36%) 11 (42%) 14 (33%)
 TT 3 (9%) 2 (2%) 4 (15%) 4 (9%)
 Allele C 45 (66%) 67 (80%) 33 (63%) 64 (74%) 0.30 0.39 0.19 0.10
 Allele T 23 (34%) 17 (20%) 19 (37%) 22 (26%)
 HWE X2 0.46 0.47 0.20 0.90  
P-value 0.71 0.99 0.68 0.42
C1818T (rs564481)
Age ≥ 57 years
 CC 9 (35%) 27 (51%) 10 (29%) 8 (30%) 0.89 0.16 0.90 0.39
 CT 14 (54%) 23 (43%) 21 (60%) 15 (56%)
 TT 3 (12%) 3 (6%) 4 (11%) 4 (15%)
 Allele C 32 (62%) 77 (72%) 40 (59%) 31 (57%) 0.81 0.10 0.98 0.22
 Allele T 20 (38%) 29 (28%) 28 (41%) 23 (43%)
 HWE X2 0.49 0.02 1.95 0.49  
P-value 0.69 0.89 0.29 0.70
  1. (1): H-Tens = Hypertension; (2): CAD + H-Tens = Coronary artery disease and hypertension; (3): CAD = Coronary artery disease; (4): Ctrl = Control. Values are presented as number (percentage). Genotypes and allele frequencies were compared among groups using chi-square/Fisher’s exact tests. *Significant difference (P<0.05)