Skip to main content

Table 2 Properties of MAMS design and running two separate trials

From: Multi-arm multi-stage trials can improve the efficiency of finding effective treatments for stroke: a case study

Design Treatments ineffective One treatment effective
Total type-I error rate Expected sample size Power to recommend effective treatment Expected sample size
MAMS, futility only, two-stage 0.033 623 0.761 834
Separate trials 0.034 992 0.644 992
Separate trials, group-sequential 0.036 608 0.625 764
Multi-arm, no interim analyses 0.036 990 0.782 990
  1. As described further in the manuscript, the ‘Treatments ineffective’ scenario uses a success probability of 0.304 for the control treatment, 0.302 for the first experimental treatment and 0.294 for the last arm. The ‘one treatment effective’ scenario uses 0.404 for one experimental treatment while the other two arms use 0.304. Statistical properties are found by approximating the log-odds ratio as normally distributed